PMID- 35250436
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Altered Brain Functional Asymmetry in Patients With Major Depressive Disorder 
      Related to Gastrointestinal Symptoms.
PG  - 797598
LID - 10.3389/fnins.2021.797598 [doi]
LID - 797598
AB  - OBJECTIVE: Disrupted brain functional asymmetry has been reported in major 
      depressive disorder (MDD). The comorbidity may be a crucial factor to this 
      functional asymmetry. It is quite common that gastrointestinal (GI) symptoms are 
      comorbid with MDD, but limited evidence focuses on the effect of GI comorbidity 
      on the neuropathology of MDD from a functional lateralization perspective. 
      METHODS: Resting-state functional magnetic resonance imaging was obtained in 28 
      healthy controls (HCs), 35 MDD patients with GI symptoms (GI-MDD patients), and 
      17 patients with MDD without GI symptoms (nGI-MDD patients). The parameter of 
      asymmetry (PAS) was used to analyze the imaging data and evaluate the changes of 
      functional asymmetry. RESULTS: The GI-MDD patients showed increased PAS scores in 
      the left inferior frontal gyrus (IFG) and superior medial prefrontal cortex 
      (MPFC) and decreased PAS scores in the right postcentral gyrus in comparison with 
      nGI-MDD patients. The PAS scores of the left IFG and left superior MPFC were 
      correlated with the severity of GI problems and could be applied to distinguish 
      GI-MDD patients from nGI-MDD patients with an accuracy, a sensitivity, and a 
      specificity of 92.31, 100, and 76.47%, respectively. Furthermore, GI-MDD and 
      nGI-MDD patients both displayed increased PAS scores in the PCC/precuneus. 
      CONCLUSIONS: This study revealed the influence of concomitant GI symptoms on 
      functional asymmetry in MDD patients. Increased PAS scores of the left IFG and 
      superior MPFC might represent an unbalanced regulation of brain over GI function 
      and had the potential to be regarded as distinctive features related to 
      functional GI symptoms in MDD.
CI  - Copyright (c) 2022 Fu, Ding, Chen, Liu, Li, Zhao and Guo.
FAU - Fu, Xiaoya
AU  - Fu X
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Ding, Yudan
AU  - Ding Y
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Chen, Jindong
AU  - Chen J
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Li, Huabing
AU  - Li H
AD  - Department of Radiology, The Second Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Guo, Wenbin
AU  - Guo W
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
AD  - Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, China.
LA  - eng
PT  - Journal Article
DEP - 20220217
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8891942
OTO - NOTNLM
OT  - asymmetry
OT  - gastrointestinal (GI) symptoms
OT  - interhemispheric connectivity
OT  - major depressive disorder (MDD)
OT  - parameter of asymmetry (PAS)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/08 06:00
MHDA- 2022/03/08 06:01
PMCR- 2021/01/01
CRDT- 2022/03/07 06:01
PHST- 2021/10/19 00:00 [received]
PHST- 2021/12/22 00:00 [accepted]
PHST- 2022/03/07 06:01 [entrez]
PHST- 2022/03/08 06:00 [pubmed]
PHST- 2022/03/08 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.797598 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Feb 17;15:797598. doi: 10.3389/fnins.2021.797598. 
      eCollection 2021.