PMID- 35250549
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - Cerebral Blood Flow Alterations in Type 2 Diabetes Mellitus: A Systematic Review 
      and Meta-Analysis of Arterial Spin Labeling Studies.
PG  - 847218
LID - 10.3389/fnagi.2022.847218 [doi]
LID - 847218
AB  - OBJECTIVE: Arterial spin labeling (ASL) studies have revealed inconsistent 
      regional cerebral blood flow (CBF) alterations in patients with type 2 diabetes 
      mellitus (T2DM). The aim of this systematic review and meta-analysis was to 
      identify concordant regional CBF alterations in T2DM. METHODS: A systematic 
      review was conducted to the published literatures comparing cerebral perfusion 
      between patients with T2DM and healthy controls using ASL. The seed-based d 
      mapping (SDM) was further used to perform quantitative meta-analysis on 
      voxel-based literatures and to estimate the regional CBF alterations in patients 
      with T2DM. Metaregression was performed to explore the associations between 
      clinical characteristics and cerebral perfusion alterations. RESULTS: A total of 
      13 studies with 14 reports were included in the systematic review and 7 studies 
      with 7 reports were included in the quantitative meta-analysis. The qualitative 
      review found widespread CBF reduction in cerebral lobes in T2DM. The 
      meta-analysis found increased regional CBF in right supplementary motor area and 
      decreased regional CBF in bilateral middle occipital gyrus, left caudate nucleus, 
      right superior parietal gyrus, and left calcarine fissure/surrounding cortex in 
      T2DM. CONCLUSION: The patterns of cerebral perfusion alterations, characterized 
      by the decreased CBF in occipital and parietal lobes, might be the neuropathology 
      of visual impairment and cognitive aging in T2DM.
CI  - Copyright (c) 2022 Liu, Yang, Li, Xu, Ren and Zhou.
FAU - Liu, Jieke
AU  - Liu J
AD  - Department of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan 
      Cancer Hospital and Institute, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Yang, Xi
AU  - Yang X
AD  - Department of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan 
      Cancer Hospital and Institute, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Li, Yong
AU  - Li Y
AD  - Department of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan 
      Cancer Hospital and Institute, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Xu, Hao
AU  - Xu H
AD  - Department of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan 
      Cancer Hospital and Institute, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Ren, Jing
AU  - Ren J
AD  - Department of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan 
      Cancer Hospital and Institute, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Zhou, Peng
AU  - Zhou P
AD  - Department of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan 
      Cancer Hospital and Institute, University of Electronic Science and Technology of 
      China, Chengdu, China.
LA  - eng
PT  - Systematic Review
DEP - 20220216
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8888831
OTO - NOTNLM
OT  - arterial spin labeling
OT  - cerebral blood flow
OT  - meta-analysis
OT  - seed-based d mapping
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/08 06:00
MHDA- 2022/03/08 06:01
PMCR- 2022/01/01
CRDT- 2022/03/07 06:02
PHST- 2022/01/01 00:00 [received]
PHST- 2022/01/26 00:00 [accepted]
PHST- 2022/03/07 06:02 [entrez]
PHST- 2022/03/08 06:00 [pubmed]
PHST- 2022/03/08 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.847218 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Feb 16;14:847218. doi: 10.3389/fnagi.2022.847218. 
      eCollection 2022.