PMID- 35250848
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220502
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Associations Between Different Dietary Vitamins and the Risk of Obesity in 
      Children and Adolescents: A Machine Learning Approach.
PG  - 816975
LID - 10.3389/fendo.2021.816975 [doi]
LID - 816975
AB  - BACKGROUNDS: Simultaneous dietary intake of vitamins is considered as a common 
      and real scenario in daily life. However, limited prospective studies have 
      evaluated the association between multivitamins intake and obesity in children 
      and adolescents. OBJECTIVES: This study aimed to evaluate the relationship 
      between the intake of different dietary vitamins and the risk of obesity in 
      children (6-11 years) and adolescents (12-19 years). METHODS: We conducted a 
      cross-sectional study based on data from U.S. National Health and Nutrition 
      Examination Survey, 2013-2016. A total of 3634 children and adolescents were 
      included who had available data on dietary vitamins, obesity and covariates. We 
      analyzed the dietary intake levels of nine vitamins, including vitamin A, vitamin 
      B(1), vitamin B(2), vitamin B(6), vitamin B(12), vitamin C, vitamin D, vitamin E, 
      vitamin K. Multivariate logistic regression was used to model the associations 
      between vitamins and obesity. Bayesian kernel machine regression (BKMR) was 
      employed to explore the joint and independent effects of vitamins on obesity 
      among children and adolescents. RESULTS: In the multivariate logistic regression 
      model, five vitamins (vitamin A, vitamin B(1), vitamin B(2), vitamin B(12), and 
      vitamin D) were negatively associated with obesity in children and adolescents. 
      BKMR analysis showed that when the concentration of the nine vitamins was at or 
      above the 55th percentile compared with the median value, the combined intake of 
      these vitamins could significantly reduce the risk of obesity in children and 
      adolescents. Potential interactions between vitamin B(2) and vitamin B(12) in 
      increasing the risk of obesity in children and adolescents were observed. 
      CONCLUSIONS: We determine the combined effects of multivitamins on obesity in 
      children and adolescents, and observe a significant interaction between vitamin 
      B(2) and vitamin B(12). Further cohort studies are needed to clarify the health 
      effects of multivitamins intake in a larger population.
CI  - Copyright (c) 2022 Tang, Zhan, Wei and Chen.
FAU - Tang, Weifeng
AU  - Tang W
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Zhan, Wenqiang
AU  - Zhan W
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Wei, Mengdan
AU  - Wei M
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220217
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Vitamins)
RN  - 11103-57-4 (Vitamin A)
RN  - 12001-79-5 (Vitamin K)
RN  - 1406-16-2 (Vitamin D)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adolescent
MH  - Bayes Theorem
MH  - Child
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Machine Learning
MH  - Nutrition Surveys
MH  - *Pediatric Obesity/epidemiology/etiology
MH  - Prospective Studies
MH  - Vitamin A
MH  - Vitamin B 12
MH  - Vitamin D
MH  - Vitamin K
MH  - Vitamins
PMC - PMC8893992
OTO - NOTNLM
OT  - *Bayesian Kernel machine regressioN
OT  - *adolescents
OT  - *children
OT  - *diet
OT  - *multivitamins
OT  - *obesity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/08 06:00
MHDA- 2022/04/23 06:00
PMCR- 2021/01/01
CRDT- 2022/03/07 06:02
PHST- 2021/11/17 00:00 [received]
PHST- 2021/12/29 00:00 [accepted]
PHST- 2022/03/07 06:02 [entrez]
PHST- 2022/03/08 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.816975 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Feb 17;12:816975. doi: 
      10.3389/fendo.2021.816975. eCollection 2021.