PMID- 35250958
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220308
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 13
DP  - 2022
TI  - The Dynamic Change of Immune Responses Between Acute and Recurrence Stages of 
      Rodent Malaria Infection.
PG  - 844975
LID - 10.3389/fmicb.2022.844975 [doi]
LID - 844975
AB  - Malaria infections are persistent as frequent recrudescence of the disease may 
      occur following the acute infection stage, but the different immune responses 
      that control the acute and recrudescence stages are still largely unknown. Using 
      single-cell RNA sequencing (scRNA-seq), we showed that the number of Th1 and 
      plasma cells in the spleen was significantly reduced during the recurrence stage 
      compared to the acute stage of Plasmodium chabaudi chabaudi AS (P. chabaudi) 
      infection. Additionally, the ability of both CD4(+) T cell responses and B cells 
      to control P. chabaudi recurrence was significantly reduced compared to their 
      roles in the control of acute infection. In contrast, the number of innate immune 
      cells, including red pulp macrophages (RPMs), gamma delta (gammadelta) T cells, and 
      Dendritic cells (DCs) were significantly increased during the recurrence stage 
      and showed to be critical for P. chabaudi infection recurrence control. Thus, our 
      data strongly suggest the complementary role of innate immune responses in 
      controlling malaria recrudescence when adaptive immune responses are suppressed. 
      These findings shed new light on the development of immune interventions against 
      malaria.
CI  - Copyright (c) 2022 Chen, Gao, Fan, Guo, Zhou, Liu and Xu.
FAU - Chen, Suilin
AU  - Chen S
AD  - Department of Pathogenic Biology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
AD  - Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, 
      Chongqing, China.
FAU - Gao, Yuanli
AU  - Gao Y
AD  - Department of Pathogenic Biology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
AD  - Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, 
      Chongqing, China.
FAU - Fan, Yongling
AU  - Fan Y
AD  - Department of Pathogenic Biology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
AD  - Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, 
      Chongqing, China.
FAU - Guo, Shuai
AU  - Guo S
AD  - Department of Pathogenic Biology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
AD  - Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, 
      Chongqing, China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Institute of Immunology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
FAU - Liu, Taiping
AU  - Liu T
AD  - Department of Pathogenic Biology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
AD  - Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, 
      Chongqing, China.
FAU - Xu, Wenyue
AU  - Xu W
AD  - Department of Pathogenic Biology, Army Medical University (Third Military Medical 
      University), Chongqing, China.
AD  - Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, 
      Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20220217
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC8891988
OTO - NOTNLM
OT  - adaptive immune responses
OT  - innate immune responses
OT  - malaria parasite
OT  - recurrence
OT  - scRNA-seq
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/08 06:00
MHDA- 2022/03/08 06:01
PMCR- 2022/02/17
CRDT- 2022/03/07 06:03
PHST- 2021/12/29 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/03/07 06:03 [entrez]
PHST- 2022/03/08 06:00 [pubmed]
PHST- 2022/03/08 06:01 [medline]
PHST- 2022/02/17 00:00 [pmc-release]
AID - 10.3389/fmicb.2022.844975 [doi]
PST - epublish
SO  - Front Microbiol. 2022 Feb 17;13:844975. doi: 10.3389/fmicb.2022.844975. 
      eCollection 2022.