PMID- 35251009 OWN - NLM STAT- MEDLINE DCOM- 20220502 LR - 20220502 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 13 DP - 2022 TI - A Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives. PG - 826732 LID - 10.3389/fimmu.2022.826732 [doi] LID - 826732 AB - Kidney disease encompasses a complex set of diseases that can aggravate or start systemic pathophysiological processes through their complex metabolic mechanisms and effects on body homoeostasis. The prevalence of kidney disease has increased dramatically over the last two decades. CD4(+)CD25(+) regulatory T (Treg) cells that express the transcription factor forkhead box protein 3 (Foxp3) are critical for maintaining immune homeostasis and preventing autoimmune disease and tissue damage caused by excessive or unnecessary immune activation, including autoimmune kidney diseases. Recent studies have highlighted the critical role of metabolic reprogramming in controlling the plasticity, stability, and function of Treg cells. They are also likely to play a vital role in limiting kidney transplant rejection and potentially promoting transplant tolerance. Metabolic pathways, such as mitochondrial function, glycolysis, lipid synthesis, glutaminolysis, and mammalian target of rapamycin (mTOR) activation, are involved in the development of renal diseases by modulating the function and proliferation of Treg cells. Targeting metabolic pathways to alter Treg cells can offer a promising method for renal disease therapy. In this review, we provide a new perspective on the role of Treg cell metabolism in renal diseases by presenting the renal microenvironment、relevant metabolites of Treg cell metabolism, and the role of Treg cell metabolism in various kidney diseases. CI - Copyright (c) 2022 Han, Ma, Tao, Liu, Zhang, Sai, Li, Chi, Nian, Song and Liu. FAU - Han, Zhongyu AU - Han Z AD - Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China. AD - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. AD - Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Ma, Kuai AU - Ma K AD - Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan. FAU - Tao, Hongxia AU - Tao H AD - Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Liu, Hongli AU - Liu H AD - Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhang, Jiong AU - Zhang J AD - Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China. AD - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. FAU - Sai, Xiyalatu AU - Sai X AD - Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China. FAU - Li, Yunlong AU - Li Y AD - Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Chi, Mingxuan AU - Chi M AD - Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China. AD - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. FAU - Nian, Qing AU - Nian Q AD - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. AD - Department of Blood Transfusion Sicuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Song, Linjiang AU - Song L AD - Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Liu, Chi AU - Liu C AD - Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, University of Electronic Science and Technology of China, Chengdu, China. AD - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20220217 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Forkhead Transcription Factors) SB - IM MH - *Autoimmune Diseases/metabolism MH - Female MH - Forkhead Transcription Factors/metabolism MH - Humans MH - *Kidney Diseases/metabolism MH - Male MH - T-Lymphocytes, Regulatory MH - Transplantation Tolerance PMC - PMC8892604 OTO - NOTNLM OT - immune homeostasis OT - metabolic pathways OT - regulatory T cells OT - renal disease OT - tissue damage COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/03/08 06:00 MHDA- 2022/05/03 06:00 PMCR- 2022/01/01 CRDT- 2022/03/07 06:03 PHST- 2021/12/01 00:00 [received] PHST- 2022/01/24 00:00 [accepted] PHST- 2022/03/07 06:03 [entrez] PHST- 2022/03/08 06:00 [pubmed] PHST- 2022/05/03 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2022.826732 [doi] PST - epublish SO - Front Immunol. 2022 Feb 17;13:826732. doi: 10.3389/fimmu.2022.826732. eCollection 2022.