PMID- 35251642 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231103 IS - 2049-9469 (Electronic) IS - 2049-9450 (Print) IS - 2049-9450 (Linking) VI - 16 IP - 4 DP - 2022 Apr TI - Cancer cachexia as a determinant of efficacy of first-line pembrolizumab in patients with advanced non-small cell lung cancer. PG - 91 LID - 10.3892/mco.2022.2524 [doi] LID - 91 AB - Pembrolizumab, either as a type of monotherapy or in combination with cytotoxic anticancer agents, is effective in the treatment of advanced non-small cell lung cancer (NSCLC). However, the development of cancer cachexia may adversely affect anticancer drug therapy. The present study investigated the effect of cancer cachexia on clinical outcomes in patients with advanced NSCLC who received first-line pembrolizumab. The data of patients with advanced NSCLC receiving first-line monotherapy or combination therapy with pembrolizumab were retrospectively analyzed. The primary endpoint was time to treatment failure (TTF), and the secondary endpoints were overall survival (OS) and incidence of adverse events (AEs). Clinical outcome was compared between patients with and without cancer cachexia. A total of 53 patients were analyzed. Among all patients, median TTF and OS were significantly shorter in patients with cancer cachexia than in those without [TTF: 5.8 vs. 10 months; hazard ratio (HR): 2.13; 95% confidence interval (CI): 1.07-4.24; P=0.016; OS: 12.1 months vs. not reached; HR: 5.85; 95% CI: 2.0-17.1; P=0.001]. In addition, TTF in the pembrolizumab monotherapy group was significantly shorter in patients with cancer cachexia than in those without, but no significant difference was detected in patients receiving pembrolizumab combination therapy. The incidence of AEs did not significantly differ between patients with and without cancer cachexia, except with regard to hypothyroidism. In conclusion, although cancer cachexia is prognostic of a poor outcome in patients with advanced NSCLC who receive first-line pembrolizumab, cancer cachexia might not affect therapeutic efficacy in combination therapy with pembrolizumab and cytotoxic anticancer agents. CI - Copyright: (c) Fujii et al. FAU - Fujii, Hironori AU - Fujii H AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Araki, Ayumu AU - Araki A AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Iihara, Hirotoshi AU - Iihara H AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Kaito, Daizo AU - Kaito D AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Hirose, Chiemi AU - Hirose C AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Kinomura, Motohiko AU - Kinomura M AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Yamazaki, Mizuki AU - Yamazaki M AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Endo, Junki AU - Endo J AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Inui, Toshiya AU - Inui T AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Yanase, Komei AU - Yanase K AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Sasaki, Yuka AU - Sasaki Y AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Gomyo, Takenobu AU - Gomyo T AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Sakai, Chizuru AU - Sakai C AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Kawae, Daisuke AU - Kawae D AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Kitamura, Yu AU - Kitamura Y AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Fukui, Masachika AU - Fukui M AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Kobayashi, Ryo AU - Kobayashi R AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Ohno, Yasushi AU - Ohno Y AD - Department of Cardiology and Respirology Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. FAU - Suzuki, Akio AU - Suzuki A AD - Department of Pharmacy, Gifu University Hospital, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. LA - eng PT - Journal Article DEP - 20220224 PL - England TA - Mol Clin Oncol JT - Molecular and clinical oncology JID - 101613422 PMC - PMC8892465 OTO - NOTNLM OT - advanced non-small cell lung cancer OT - cancer cachexia OT - overall survival OT - pembrolizumab OT - time to treatment failure COIS- The authors declare that they have no competing interests. EDAT- 2022/03/08 06:00 MHDA- 2022/03/08 06:01 PMCR- 2022/02/24 CRDT- 2022/03/07 06:05 PHST- 2021/11/19 00:00 [received] PHST- 2022/01/12 00:00 [accepted] PHST- 2022/03/07 06:05 [entrez] PHST- 2022/03/08 06:00 [pubmed] PHST- 2022/03/08 06:01 [medline] PHST- 2022/02/24 00:00 [pmc-release] AID - MCO-16-4-02524 [pii] AID - 10.3892/mco.2022.2524 [doi] PST - ppublish SO - Mol Clin Oncol. 2022 Apr;16(4):91. doi: 10.3892/mco.2022.2524. Epub 2022 Feb 24.