PMID- 35252540
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 39
DP  - 2022 Apr
TI  - Predictors of echocardiographic response to cardiac resynchronization therapy: A 
      systematic review with Meta-Analysis.
PG  - 100979
LID - 10.1016/j.ijcha.2022.100979 [doi]
LID - 100979
AB  - BACKGROUND: At least 30% of the patients do not respond to cardiac 
      resynchronization therapy (CRT). We performed a systematic review and 
      meta-analysis of real-world studies trying to identify predictors of response to 
      CRT. METHODS: PubMed, Embase and Cochrane Central Register of Controlled Trials 
      (CENTRAL) were searched for observational prospective studies, referring the 
      evaluation of response to CRT, defined as a decrease in left ventricle 
      end-systolic volume (LVESV) >/= 15% at 6-month follow-up, via two-dimensional 
      echocardiography. RESULTS: A total of 24 studies were included. The meta-analysis 
      showed that female gender (p = 0.018), non-ischemic cardiomyopathy (NICM) 
      (p < 0.001), left bundle branch morphology (LBBB) (p = 0.001), longer QRS 
      (p < 0.001) and New York Heart Association (NYHA) class II (p = 0.014) appear to 
      favor response to CRT. After ROC analysis and logistic regression procedures, 
      female gender (kappa = 0.450; p < 0.001), NICM (kappa = 0.636; p < 0.001), LBBB 
      (kappa = 0.935; p < 0.001), and NYHA class II (kappa = 0.647; p < 0.001) were 
      identified as independent predictors of response to CRT, being LBBB the most 
      reliable one (sensitivity = 97.24%; specificity = 98.86%). CONCLUSIONS: Female 
      gender, NICM, LBBB and NYHA class II are baseline variables with an apparent 
      capability to independently predict response to CRT, being LBBB the most reliable 
      one.
CI  - (c) 2022 Published by Elsevier B.V.
FAU - Martins, Rodrigo
AU  - Martins R
AD  - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.
FAU - Antonio, Natalia
AU  - Antonio N
AD  - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.
AD  - Servico de Cardiologia, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal.
FAU - Donato, Helena
AU  - Donato H
AD  - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.
AD  - Servico de Documentacao, Centro Hospitalar e Universitario de Coimbra, Coimbra, 
      Portugal.
FAU - Oliveiros, Barbara
AU  - Oliveiros B
AD  - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220228
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC8891947
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - Left bundle branch block
OT  - Left ventricular remodeling
OT  - Predictors
OT  - Response
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/03/08 06:00
MHDA- 2022/03/08 06:01
PMCR- 2022/02/28
CRDT- 2022/03/07 06:09
PHST- 2021/12/26 00:00 [received]
PHST- 2022/01/30 00:00 [revised]
PHST- 2022/02/20 00:00 [accepted]
PHST- 2022/03/07 06:09 [entrez]
PHST- 2022/03/08 06:00 [pubmed]
PHST- 2022/03/08 06:01 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - S2352-9067(22)00028-8 [pii]
AID - 100979 [pii]
AID - 10.1016/j.ijcha.2022.100979 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2022 Feb 28;39:100979. doi: 
      10.1016/j.ijcha.2022.100979. eCollection 2022 Apr.