PMID- 35254023
OWN - NLM
STAT- MEDLINE
DCOM- 20220309
LR  - 20220309
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 68
IP  - 3
DP  - 2022 Mar 1
TI  - A Descriptive Study of Total Serum Homocysteine Status in Adult Henan Province, 
      China.
LID - 10.7754/Clin.Lab.2021.210531 [doi]
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy) is an independent risk factor for 
      cardiovascular disease. Total serum homocysteine (tHcy) status varies greatly 
      with ethnicity and gender. Here, we studied the tHcy status by investigating 
      concentration of tHcy and calculating prevalence of HHcy according to different 
      age groups and genders. METHODS: This is a cross-sectional study of 10,258 
      participants (7,248 males and 3,010 females) above 19 years old from Henan 
      Province, northern China. tHcy levels were determined enzymatically. HHcy was 
      defined as a tHcy level higher than 15 mumol/L. RESULTS: In the whole population, 
      the median value of tHcy was 13.56 (11.50, 16.50) mumol/L, and the HHcy prevalence 
      was 34.61%. Males had much higher tHcy levels than females: 14.51 (12.58, 17.71) 
      mumol/L vs. 11.23 (9.75, 12.97) mumol/L, p < 0.001. Also, males had much higher 
      HHcy prevalence than females (44.33% vs. 11.20%, p < 0.001, OR = 6.33, 95% CI: 
      5.59 - 7.14). HHcy prevalence and tHcy levels increased greatly for both genders 
      above 60 years old. CONCLUSIONS: Our results demonstrated that prevalence of HHcy 
      is very high in northern China. Implementation of tHcy-lowering strategies is 
      needed.
FAU - Liu, Xia'nan
AU  - Liu X
FAU - Wang, Xuebin
AU  - Wang X
FAU - Gao, Yuhua
AU  - Gao Y
FAU - Fu, Guangzhen
AU  - Fu G
FAU - Ming, Liang
AU  - Ming L
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia/diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
EDAT- 2022/03/08 06:00
MHDA- 2022/03/11 06:00
CRDT- 2022/03/07 10:34
PHST- 2022/03/07 10:34 [entrez]
PHST- 2022/03/08 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
AID - 10.7754/Clin.Lab.2021.210531 [doi]
PST - ppublish
SO  - Clin Lab. 2022 Mar 1;68(3). doi: 10.7754/Clin.Lab.2021.210531.