PMID- 35257465
OWN - NLM
STAT- MEDLINE
DCOM- 20220915
LR  - 20221011
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Print)
IS  - 1444-0903 (Linking)
VI  - 52
IP  - 9
DP  - 2022 Sep
TI  - Pilot study for immunoglobulin E as a prognostic biomarker in coronavirus disease 
      2019.
PG  - 1495-1504
LID - 10.1111/imj.15728 [doi]
AB  - BACKGROUND: Laboratory biomarkers to estimate the severity of coronavirus disease 
      2019 (COVID-19) are crucial during the pandemic since resource allocation must be 
      carefully planned. AIMS: To evaluate the effects of basal serum total 
      immunoglobulin E (IgE) levels and changes in inflammatory parameters on the 
      clinical progression of patients hospitalised with COVID-19. METHODS: Patients 
      hospitalised with confirmed COVID-19 were included in the study. Laboratory data 
      and total IgE levels were measured on admission. Lymphocyte, eosinophil, 
      ferritin, d-dimer and C-reactive protein parameters were recorded at baseline and 
      on the 3rd and 14th days of hospitalisation. RESULTS: The study enrolled 202 
      patients, of which 102 (50.5%) were males. The average age was 50.17 +/- 19.68 
      years. Of the COVID-19 patients, 41 (20.3%) showed clinical progression. Serum 
      total IgE concentrations were markedly higher (172.90 (0-2124) vs 38.70 (0-912); 
      P < 0.001) and serum eosinophil levels were significantly lower (0.015 (0-1.200) 
      vs 0.040 (0-1.360); P = 0.002) in clinically worsened COVID-19 patients when 
      compared with stable patients. The optimal cut-off for predicting clinical 
      worsening was 105.2 ng/L, with 61% sensitivity, 82% specificity, 46.3% positive 
      predictive value and 89.2% negative predictive value (area under the 
      curve = 0.729). Multivariable analysis to define risk factors for disease 
      progression identified higher total IgE and C-reactive protein levels as 
      independent predictors. CONCLUSIONS: Our single-centre pilot study determined 
      that total IgE levels may be a negative prognostic factor for clinical 
      progression in patients hospitalised due to COVID-19 infection. Future studies 
      are required to determine the impact of individuals' underlying immune 
      predispositions on outcomes of COVID-19 infections.
CI  - (c) 2022 Royal Australasian College of Physicians.
FAU - Aydin Guclu, Ozge
AU  - Aydin Guclu O
AUID- ORCID: 0000-0003-1005-3205
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
AD  - Department of Pulmonary Disease, Boyabat 75th Year State Hospital, Sinop, Turkey.
FAU - Goktas, Seda S
AU  - Goktas SS
AD  - Department of Otolaryngology, Boyabat 75th Year State Hospital, Sinop, Turkey.
FAU - Gorek Dilektasli, Asli
AU  - Gorek Dilektasli A
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
FAU - Acet Ozturk, Nilufer A
AU  - Acet Ozturk NA
AUID- ORCID: 0000-0002-6375-1472
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
FAU - Demirdogen, Ezgi
AU  - Demirdogen E
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
FAU - Coskun, Funda
AU  - Coskun F
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
FAU - Ediger, Dane
AU  - Ediger D
AD  - Department of Pulmonary Diseases, Section of Immunology and Allergy Diseases, 
      Uludag University Faculty of Medicine, Bursa, Turkey.
FAU - Ursavas, Ahmet
AU  - Ursavas A
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
FAU - Uzaslan, Esra
AU  - Uzaslan E
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
FAU - Erol, Hasim A
AU  - Erol HA
AD  - Department of Internal Medicine, Boyabat 75th Year State Hospital, Sinop, Turkey.
FAU - Karacay, Nurdan D
AU  - Karacay ND
AD  - Department of Internal Medicine, Boyabat 75th Year State Hospital, Sinop, Turkey.
FAU - Kaya Sel, Umut
AU  - Kaya Sel U
AD  - Department of Anesthesiology and Intensive Care, Boyabat 75th Year State 
      Hospital, Sinop, Turkey.
FAU - Karadag, Mehmet
AU  - Karadag M
AD  - Department of Pulmonary Diseases, Uludag University Faculty of Medicine, Bursa, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - C-Reactive Protein
MH  - *COVID-19
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prognosis
MH  - Retrospective Studies
MH  - SARS-CoV-2
PMC - PMC9111421
OTO - NOTNLM
OT  - COVID-19
OT  - clinical progression
OT  - eosinophil
OT  - pilot study
OT  - total IgE
EDAT- 2022/03/09 06:00
MHDA- 2022/09/16 06:00
PMCR- 2022/03/07
CRDT- 2022/03/08 05:42
PHST- 2022/02/14 00:00 [revised]
PHST- 2021/10/22 00:00 [received]
PHST- 2022/02/27 00:00 [accepted]
PHST- 2022/03/09 06:00 [pubmed]
PHST- 2022/09/16 06:00 [medline]
PHST- 2022/03/08 05:42 [entrez]
PHST- 2022/03/07 00:00 [pmc-release]
AID - IMJ15728 [pii]
AID - 10.1111/imj.15728 [doi]
PST - ppublish
SO  - Intern Med J. 2022 Sep;52(9):1495-1504. doi: 10.1111/imj.15728. Epub 2022 Aug 19.