PMID- 35257550
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 50
IP  - 2
DP  - 2022
TI  - Investigation of the sensitization rate for gibberellin-regulated protein in 
      patients with Japanese cedar pollinosis.
PG  - 89-92
LID - 10.15586/aei.v50i2.440 [doi]
AB  - BACKGROUND: Pollen-food allergy syndrome (PFAS) usually manifests as an itching 
      sensation in the mouth and throat immediately after eating fresh fruits and 
      vegetables. However, some patients with PFAS experience systemic symptoms 
      including anaphylaxis. In Europe, cypress gibberellin-regulated protein (GRP) has 
      been noted to cause allergenicity and exhibit cross-reactivity with peach GRP. 
      Japanese cedar (Cryptomeria japonica), classified in the cypress family, is the 
      primary causative substance among all environmental allergens in Japan. However, 
      studies on the prevalence of GRP sensitization in patients with cedar pollinosis 
      are lacking. OBJECTIVE: This study examined the prevalence of GRP sensitization 
      in patients with Japanese cedar pollinosis. METHODS: We enrolled 52 patients who 
      had requested sublingual immunotherapy treatment with mild-to-severe rhinitis 
      during spring, and had a JCP-specific immunoglobulin E (IgE) levels of >0.7 
      U(A)/mL. Peach GRP was purified using affinity chromatography with a monoclonal 
      antibody column. Specific IgE levels to peach GRP were measured using an 
      enzyme-linked immunosorbent assay. Samples exhibiting absorbance at 450 nm of 
      over mean plus three standard deviations of the negative control value were 
      defined as positive. Sera from three patients with severe peach allergy were used 
      as positive controls. RESULTS: Eleven sera from 52 patients with JCP-induced 
      allergic rhinitis were positive for peach GRP. CONCLUSION: Twenty percent of 
      patients with cedar pollinosis were sensitized to peach GRP. Well-powered studies 
      are needed to clarify whether these patients are at an increased risk for 
      systemic symptoms or whether they primarily demonstrate only localized symptoms.
FAU - Mori, Yuji
AU  - Mori Y
AD  - Department of Pediatrics, School of Medicine, Fujita Health University, Aichi, 
      Japan.
FAU - Okazaki, Fumiko
AU  - Okazaki F
AD  - Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku 
      University, Shiga, Japan.
FAU - Momma, Keiko
AU  - Momma K
AD  - Department of Food and Nutrition, Kyoto Women's University, Kyoto, Japan.
FAU - Narita, Hiroshi
AU  - Narita H
AD  - Kyoto College of Nutritional and Medical Sciences, Kyoto, Japan.
FAU - Kondo, Yasuto
AU  - Kondo Y
AD  - Department of Pediatrics, School of Medicine, Fujita Health University, Aichi, 
      Japan; ykondo@fujita-hu.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20220301
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Allergens)
RN  - 0 (Gibberellins)
SB  - IM
MH  - Allergens
MH  - *Cryptomeria
MH  - Gibberellins
MH  - Humans
MH  - Pollen
MH  - *Rhinitis, Allergic, Seasonal
OTO - NOTNLM
OT  - Japanese cedar
OT  - gibberellin-regulated protein
OT  - peach
OT  - pollen-food allergy syndrome
OT  - sensitization
EDAT- 2022/03/09 06:00
MHDA- 2022/04/07 06:00
CRDT- 2022/03/08 05:43
PHST- 2021/05/06 00:00 [received]
PHST- 2021/11/28 00:00 [accepted]
PHST- 2022/03/08 05:43 [entrez]
PHST- 2022/03/09 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
AID - 10.15586/aei.v50i2.440 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2022 Mar 1;50(2):89-92. doi: 
      10.15586/aei.v50i2.440. eCollection 2022.