PMID- 35257916
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220915
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 84
DP  - 2022 Aug
TI  - Elevated Remnant Lipoprotein Related to Adverse Events in Patients with Chronic 
      Limb-Threatening Ischemia after Endovascular Therapy for Below-the-Knee Lesions.
PG  - 314-321
LID - S0890-5096(22)00068-1 [pii]
LID - 10.1016/j.avsg.2022.01.024 [doi]
AB  - BACKGROUND: The prognosis of patients with chronic limb-threatening ischemia 
      (CLTI) is unacceptably poor, and risk factors are unknown. Serum remnant 
      lipoprotein has been associated with cardiovascular events. The aim of our study 
      was to test the hypothesis that remnant lipoprotein is associated with the 
      prognosis of patients with CLTI. METHODS: This retrospective study included 67 
      patients with CLTI who had received endovascular therapy (EVT) for de novo 
      below-the-knee lesions. Patients were divided into 2 groups using fasting 
      preoperative value of remnant-like particle cholesterol (RLP-C) with a cutoff 
      value of 5.1 mg/dL into LOW RLP-C (n = 46) and HIGH RLP-C (n = 21). We assessed 
      the differences between the 2 groups in the prevalence of major adverse limb 
      events (MALE), composed of target lesion revascularization and major amputation. 
      RESULTS: At a median follow-up period of 12 months, MALE had occurred in 11 LOW 
      RLP-C patients (23.9%) and 11 HIGH RLP-C patients (52.4%; P = 0.03). Kaplan-Meier 
      analysis showed the prevalence of MALE was significantly higher in HIGH RLP-C 
      than LOW RLP-C (log-rank chi(2) = 5.2, P = 0.02). Multivariate analysis found HIGH 
      RLP-C to be an independent predictor for MALE (hazard ratio, 2.6; 95% confidence 
      interval, 1.1-6.1; P = 0.02) along with history of coronary artery disease. 
      CONCLUSIONS: Preoperative remnant lipoprotein was associated with the prognosis 
      of patients with CLTI who had received EVT for de novo below-the-knee lesions.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Ito, Naruhiko
AU  - Ito N
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan. Electronic 
      address: nito0516@yahoo.co.jp.
FAU - Hishikari, Keiichi
AU  - Hishikari K
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Yoshikawa, Hiroshi
AU  - Yoshikawa H
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Yano, Hirotaka
AU  - Yano H
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Iiya, Munehiro
AU  - Iiya M
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Murai, Tadashi
AU  - Murai T
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Hikita, Hiroyuki
AU  - Hikita H
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Takahashi, Atsushi
AU  - Takahashi A
AD  - Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
FAU - Yonetsu, Taishi
AU  - Yonetsu T
AD  - Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Sasano, Tetsuo
AU  - Sasano T
AD  - Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220304
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - 0 (Lipoproteins)
SB  - IM
MH  - *Chronic Limb-Threatening Ischemia
MH  - *Endovascular Procedures/adverse effects
MH  - Humans
MH  - Ischemia/diagnostic imaging/surgery
MH  - Knee
MH  - Lipoproteins
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2022/03/09 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/03/08 08:45
PHST- 2021/11/27 00:00 [received]
PHST- 2022/01/18 00:00 [revised]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/03/09 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/03/08 08:45 [entrez]
AID - S0890-5096(22)00068-1 [pii]
AID - 10.1016/j.avsg.2022.01.024 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2022 Aug;84:314-321. doi: 10.1016/j.avsg.2022.01.024. Epub 2022 
      Mar 4.