PMID- 35259385 OWN - NLM STAT- MEDLINE DCOM- 20220516 LR - 20220516 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 828 DP - 2022 Jul 1 TI - Association between mixed exposure of phthalates and cognitive function among the U.S. elderly from NHANES 2011-2014: Three statistical models. PG - 154362 LID - S0048-9697(22)01455-3 [pii] LID - 10.1016/j.scitotenv.2022.154362 [doi] AB - BACKGROUND: Studies on the relationship between phthalate exposure and cognition in adults are sparse and inconsistent. These studies only assessed their association of single phthalates for one-time and the tools for assessing cognitive function were different. OBJECTIVE: We aimed to examine the association between mixed phthalates and cognition in the U.S elderly using three statistical models. METHODS: The generalized linear (GLM), weighted quantile sum (WQS), and Bayesian kernel machine regression (BKMR) models were used to evaluate the associations between mixed phthalates and the standardized z-scores of four cognitive tests [Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST)] in participants aged over 60 years from NHANES 2011-2014. RESULTS: 835 individuals were included and the median raw scores of IRT, DRT, AFT, and DSST were 19 (IQR: 16-23), 6 (IQR: 5-8), 16 (IQR: 13-20), 46 (IQR: 35-59). In adjusted GLM, negative associations were observed between MECPP, MnBP, MCOP, MCPP, and the IRT z-scores; MCPP, MBzP, and the DRT z-scores. Positive relationships were found between MCOP, MCPP, and the AFT z-scores; MCPP and the DSST z-scores. The WQS index was associated with the IRT z-scores (beta(95%CI): -0.069(-0.118, -0.020)), where MCPP weighted the highest. In the BKMR, negative overall trends between the mixture and the IRT, DRT z-scores were observed when the mixture was at 40th to 65th percentile, 65th percentile or above it, respectively, where MnBP and MBzP drove the main effect of the mixture. CONCLUSION: This study is an academic exploration of the association between phthalates exposure and cognitive function, suggesting that exposure to phthalates might be associated with bad performance in IRT and DRT in the U.S. elderly. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Weng, Xueqiong AU - Weng X AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Tan, Yuxuan AU - Tan Y AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Fei, Qiaoyuan AU - Fei Q AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Yao, Huojie AU - Yao H AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Fu, Yingyin AU - Fu Y AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Wu, Xiaomei AU - Wu X AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Zeng, Huixian AU - Zeng H AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Yang, Zhiyu AU - Yang Z AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Zeng, Zurui AU - Zeng Z AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Liang, Huanzhu AU - Liang H AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Wu, Yingying AU - Wu Y AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Wen, Lin AU - Wen L AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China. FAU - Jing, Chunxia AU - Jing C AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, No. 601 Huangpu Ave West, Guangzhou 510632, Guangdong, China; Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, Guangdong, China. Electronic address: jcxphd@gmail.com. LA - eng PT - Journal Article DEP - 20220306 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Environmental Pollutants) RN - 0 (Phthalic Acids) RN - 6O7F7IX66E (phthalic acid) SB - IM MH - Aged MH - Animals MH - Bayes Theorem MH - Cognition MH - Environmental Exposure MH - *Environmental Pollutants/toxicity MH - Humans MH - Models, Statistical MH - Nutrition Surveys MH - *Phthalic Acids OTO - NOTNLM OT - Association OT - BKMR OT - Cognitive function OT - Mixed exposure OT - Phthalates OT - WQS COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/03/09 06:00 MHDA- 2022/05/17 06:00 CRDT- 2022/03/08 20:09 PHST- 2021/11/01 00:00 [received] PHST- 2022/02/28 00:00 [revised] PHST- 2022/03/03 00:00 [accepted] PHST- 2022/03/09 06:00 [pubmed] PHST- 2022/05/17 06:00 [medline] PHST- 2022/03/08 20:09 [entrez] AID - S0048-9697(22)01455-3 [pii] AID - 10.1016/j.scitotenv.2022.154362 [doi] PST - ppublish SO - Sci Total Environ. 2022 Jul 1;828:154362. doi: 10.1016/j.scitotenv.2022.154362. Epub 2022 Mar 6.