PMID- 35261301
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220317
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 29
IP  - 1
DP  - 2022 Dec
TI  - Intra-articular drug delivery systems for osteoarthritis therapy: shifting from 
      sustained release to enhancing penetration into cartilage.
PG  - 767-791
LID - 10.1080/10717544.2022.2048130 [doi]
AB  - Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage 
      degeneration. OA Patients are commonly given pharmacological treatment, but the 
      available treatments are not sufficiently effective. The development of 
      sustained-release drug delivery systems (DDSs) for OA may be an attractive 
      strategy to prevent rapid drug clearance and improve the half-life of a drug at 
      the joint cavity. Such delivery systems will improve the therapeutic effects of 
      anti-inflammatory effects in the joint cavity. Whereas, for disease-modifying OA 
      drugs (DMOADs) which target chondrocytes or act on mesenchymal stem cells (MSCs), 
      the cartilage-permeable DDSs are required to maximize their efficacy. This review 
      provides an overview of joint structure in healthy and pathological conditions, 
      introduces the advances of the sustained-release DDSs and the permeable DDSs, and 
      discusses the rational design of the permeable DDSs for OA treatment. We hope 
      that the ideas generated in this review will promote the development of effective 
      OA drugs in the future.
FAU - Huang, Huirong
AU  - Huang H
AD  - Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, 
      The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Lou, Zijian
AU  - Lou Z
AD  - Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, 
      The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, China.
AD  - Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Zheng, Shimin
AU  - Zheng S
AD  - Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, 
      The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Wu, Jianing
AU  - Wu J
AD  - Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, 
      The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Yao, Qing
AU  - Yao Q
AD  - School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
FAU - Chen, Ruijie
AU  - Chen R
AD  - Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, 
      The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Kou, Longfa
AU  - Kou L
AD  - Wenzhou Municipal Key Laboratory of Pediatric Pharmacy, Department of Pharmacy, 
      The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Chen, Daosen
AU  - Chen D
AD  - Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Delayed-Action Preparations)
SB  - IM
MH  - Cartilage
MH  - Delayed-Action Preparations/therapeutic use
MH  - Drug Delivery Systems
MH  - Humans
MH  - Injections, Intra-Articular
MH  - *Osteoarthritis/drug therapy
PMC - PMC8920370
OTO - NOTNLM
OT  - Drug delivery system
OT  - intra-articular
OT  - osteoarthritis
OT  - permeability
OT  - sustained-release
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2022/03/10 06:00
MHDA- 2022/03/11 06:00
PMCR- 2022/03/09
CRDT- 2022/03/09 08:42
PHST- 2022/03/09 08:42 [entrez]
PHST- 2022/03/10 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/03/09 00:00 [pmc-release]
AID - 2048130 [pii]
AID - 10.1080/10717544.2022.2048130 [doi]
PST - ppublish
SO  - Drug Deliv. 2022 Dec;29(1):767-791. doi: 10.1080/10717544.2022.2048130.