PMID- 35262797
OWN - NLM
STAT- MEDLINE
DCOM- 20230223
LR  - 20230223
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 315
IP  - 2
DP  - 2023 Mar
TI  - Association of autoimmune blistering disease, and specifically, pemphigus 
      vulgaris, with cardiovascular disease and its risk factors: a systematic review 
      and meta-analysis.
PG  - 207-213
LID - 10.1007/s00403-022-02346-y [doi]
AB  - Previous studies have found conflicting results about the association of 
      autoimmune blistering disease (AIBD) with cardiovascular disease (CVD) risk. The 
      objective of the study was to systematically review the relationship 
      of AIBD, including pemphigus vulgaris (PV), and its treatment with CVD and CVD 
      risk factors. MEDLINE, EMBASE, Cochrane, LILACS, SCOPUS, and Web of Science were 
      searched. We included all studies of CVD and CVD risk factors in AIBD patients. 
      Two reviewers performed title and/or abstract review and data extraction. Pooled 
      random-effects meta-analysis was performed. Forty papers met inclusion criteria. 
      AIBD was associated with higher odds of diabetes (DM) (odds ratio [95% confidence 
      interval]: 1.809 [1.258-2.601]), hypertension (HTN) (1.393 [1.088-1.784]), 
      dyslipidemia (2.177 [1.163-4.073]) and heart failure (1.919 [1.603-2.298]), but 
      was not associated with obesity, stroke, angina, heart attack, or arrhythmia. The 
      pooled random-effects prevalence for treatment-related adverse events (AEs) in 
      AIBD was 13.7% for DM, 10.7% for HTN, and 17.1% for CVD. Sensitivity analysis of 
      high-quality studies revealed similar results. AIBD patients have increased CVD 
      risk factors and heart failure. Systemic corticosteroid treatment results in 
      CVD-related AEs in AIBD. Increased CVD screening and prevention strategies are 
      warranted in AIBD.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Rokni, Alex M
AU  - Rokni AM
AD  - The University of Illinois at Chicago, Chicago, IL, USA.
FAU - Ayasse, Marissa
AU  - Ayasse M
AD  - NYU Langone Hospital - Long Island, Mineola, NY, USA.
FAU - Ahmed, Adnan
AU  - Ahmed A
AD  - AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, USA.
FAU - Guggina, Lauren
AU  - Guggina L
AD  - Departments of Medicine and Dermatology, Northwestern University Feinberg School 
      of Medicine, Chicago, IL, USA.
FAU - Kantor, Robert W
AU  - Kantor RW
AD  - Department of Dermatology, State University of New York Downstate Medical Center, 
      Brooklyn, NY, USA.
FAU - Silverberg, Jonathan I
AU  - Silverberg JI
AD  - Department of Dermatology, the George Washington University School of Medicine 
      and Health Sciences, 2150 Pennsylvania Avenue NW Suite 2B-425, Washington, DC, 
      20037, USA. JonathanISilverberg@Gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220309
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
SB  - IM
MH  - Humans
MH  - *Pemphigus/epidemiology
MH  - *Cardiovascular Diseases/epidemiology
MH  - *Autoimmune Diseases/complications/epidemiology
MH  - Blister
MH  - *Hypertension/epidemiology
MH  - *Heart Failure
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Comorbidity
OT  - Diabetes
OT  - Dyslipidemia
OT  - Hypertension
OT  - Pemphigus vulgaris
EDAT- 2022/03/10 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/03/09 12:33
PHST- 2021/10/27 00:00 [received]
PHST- 2022/02/23 00:00 [accepted]
PHST- 2021/10/27 00:00 [revised]
PHST- 2022/03/10 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/03/09 12:33 [entrez]
AID - 10.1007/s00403-022-02346-y [pii]
AID - 10.1007/s00403-022-02346-y [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2023 Mar;315(2):207-213. doi: 10.1007/s00403-022-02346-y. Epub 
      2022 Mar 9.