PMID- 35262912
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220707
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 128
IP  - 11
DP  - 2022 Jun 1
TI  - Safety of acupuncture in oncology: A systematic review and meta-analysis of 
      randomized controlled trials.
PG  - 2159-2173
LID - 10.1002/cncr.34165 [doi]
AB  - BACKGROUND: Acupuncture is frequently used to treat the side effects of cancer 
      treatment, but the safety of this intervention remains uncertain. The current 
      meta-analysis was conducted to assess the safety of acupuncture in oncological 
      patients. METHODS: The PubMed, Cochrane Central Register of Controlled Trials, 
      and Scopus databases were searched from their inception to August 7, 2020. 
      Randomized controlled trials in oncological patients comparing invasive 
      acupuncture with sham acupuncture, treatment as usual (TAU), or any other active 
      control were eligible. Two reviewers independently extracted data on study 
      characteristics and adverse events (AEs). Risk of bias was assessed using the 
      Cochrane Risk of Bias Tool. RESULTS: Of 4590 screened articles, 65 were included 
      in the analyses. The authors observed that acupuncture was not associated an with 
      increased risk of intervention-related AEs, nonserious AEs, serious AEs, or 
      dropout because of AEs compared with sham acupuncture and an active control. 
      Compared with TAU, acupuncture was not associated with an increased risk of 
      intervention-related AEs, serious AEs, or drop out because of AEs but was 
      associated with an increased risk for nonserious AEs (odds ratio, 3.94; 95% 
      confidence interval, 1.16-13.35; P = .03). However, the increased risk of 
      nonserious AEs compared with TAU was not robust against selection bias. The 
      meta-analyses may have been biased because of the insufficient reporting of AEs 
      in the original randomized controlled trials. CONCLUSIONS: The current review 
      indicates that acupuncture is as safe as sham acupuncture and active controls in 
      oncological patients. The authors recommend researchers heed the CONSORT 
      (Consolidated Standards of Reporting Trials) safety and harm extension for 
      reporting to capture the side effects and better investigate the risk profile of 
      acupuncture in oncology. LAY SUMMARY: According to this analysis, acupuncture is 
      a safe therapy for the treatment of patients with cancer. Acupuncture seems to be 
      safe compared with sham acupuncture and active controls.
CI  - (c) 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of 
      American Cancer Society.
FAU - Hoxtermann, Melanie D
AU  - Hoxtermann MD
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
FAU - Haller, Heidemarie
AU  - Haller H
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
FAU - Aboudamaah, Shaimaa
AU  - Aboudamaah S
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
FAU - Bachemir, Armin
AU  - Bachemir A
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
FAU - Dobos, Gustav
AU  - Dobos G
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
FAU - Cramer, Holger
AU  - Cramer H
AUID- ORCID: 0000-0002-3640-8046
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
FAU - Voiss, Petra
AU  - Voiss P
AUID- ORCID: 0000-0002-9005-0479
AD  - Evangelical Clinics Essen-Mitte, Department of Internal and Integrative Medicine, 
      Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20220308
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - *Acupuncture Therapy/adverse effects
MH  - Bias
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - Selection Bias
OTO - NOTNLM
OT  - acupuncture
OT  - adverse event
OT  - meta-analysis
OT  - neoplasms
OT  - randomized controlled trial
OT  - safety
EDAT- 2022/03/10 06:00
MHDA- 2022/05/11 06:00
CRDT- 2022/03/09 12:34
PHST- 2022/01/06 00:00 [revised]
PHST- 2021/08/27 00:00 [received]
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/03/10 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2022/03/09 12:34 [entrez]
AID - 10.1002/cncr.34165 [doi]
PST - ppublish
SO  - Cancer. 2022 Jun 1;128(11):2159-2173. doi: 10.1002/cncr.34165. Epub 2022 Mar 8.