PMID- 35263982
OWN - NLM
STAT- MEDLINE
DCOM- 20220311
LR  - 20220311
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 61
IP  - 3
DP  - 2022 Mar 1
TI  - [The 493th case: recurrent edema of bilateral lower extremeties].
PG  - 355-358
LID - 10.3760/cma.j.cn112138-20210603-00393 [doi]
AB  - A 43-year-old male patient with onset of edema caused by nephrotic proteinuria 
      and low titer of anti-M type phospholipase-A(2)-receptor (PLA(2)R) antibody was 
      diagnosed as idiopathic membranous nephropathy by renal biopsy. Administrated 
      with prednisone 40 mg once a day and cyclosporine 100 mg twice a day as 
      front-line regimen, the patient relapsed after transient partial remission. When 
      treatment was combined with cyclophosphamide 100 mg once a day, the 24-hour total 
      urine protein and titer of anti-PLA(2)R antibody were even elevated. Therefore, 
      the patient received rituximab 1 g intravenously in April 2019, October 2019 and 
      October 2020 respectively. CD19 positive B lymphocytes in peripheral blood were 
      eliminated from 71/mul to zero. Immunosuppressants and corticosteroids were 
      withdrawn successively. On the last follow-up in November 2020, the anti-PLA(2)R 
      antibody was negative, and the 24-hour total urine protein and serum albumin was 
      4.4 g and 34 g/L, respectively. This case suggested the potential efficacy of 
      rituximab for refractory membranous nephropathy. Further studies should explore 
      whether the titer of anti-PLA(2)R antibody indicates the dose of rituximab.
FAU - Xie, H Y
AU  - Xie HY
AD  - Department of Medicine, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
FAU - Chen, G
AU  - Chen G
AD  - Department of Nephrology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
FAU - Li, X M
AU  - Li XM
AD  - Department of Nephrology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
FAU - Li, Xuemei
AU  - Li X
AD  - Department of Nephrology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
LA  - chi
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Autoantibodies)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Receptors, Phospholipase A2)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - *Autoantibodies
MH  - Cyclophosphamide/therapeutic use
MH  - Edema
MH  - *Glomerulonephritis, Membranous
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Male
MH  - Receptors, Phospholipase A2
EDAT- 2022/03/11 06:00
MHDA- 2022/03/12 06:00
CRDT- 2022/03/10 02:57
PHST- 2022/03/10 02:57 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/12 06:00 [medline]
AID - 10.3760/cma.j.cn112138-20210603-00393 [doi]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2022 Mar 1;61(3):355-358. doi: 
      10.3760/cma.j.cn112138-20210603-00393.