PMID- 35265087
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220317
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection.
PG  - 843342
LID - 10.3389/fimmu.2022.843342 [doi]
LID - 843342
AB  - Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection 
      is closely related to disorders of the innate immune and delayed adaptive immune 
      systems. Dendritic cells (DCs) "bridge" innate immunity and adaptive immunity. 
      DCs have important roles in defending against SARS-CoV-2 infection. In this 
      review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 
      infection. We focus on the complex interplay between DCs and SARS-CoV-2: 
      pyroptosis-induced activation; activation of the renin-angiotensin-aldosterone 
      system; and activation of dendritic cell-specific intercellular adhesion molecule 
      3-grabbing non-integrin. We also discuss the decline in DC number, the impaired 
      antigen-presentation capability, and the reduced production of type-I interferon 
      of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential 
      mechanisms for pathological activation of DCs to understand the pattern of 
      SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination 
      and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 
      infection.
CI  - Copyright (c) 2022 Chang, Yang, Deng, Chen, Yang and Tang.
FAU - Chang, Teding
AU  - Chang T
AD  - Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji 
      Hospital, Tongji, China.
FAU - Yang, Jingzhi
AU  - Yang J
AD  - Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji 
      Hospital, Tongji, China.
FAU - Deng, Hai
AU  - Deng H
AD  - Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji 
      Hospital, Tongji, China.
FAU - Chen, Deng
AU  - Chen D
AD  - Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji 
      Hospital, Tongji, China.
FAU - Yang, XiangPing
AU  - Yang X
AD  - Department of Immunology, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Tang, Zhao-Hui
AU  - Tang ZH
AD  - Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji 
      Hospital, Tongji, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220221
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - COVID-19/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *SARS-CoV-2
PMC - PMC8898834
OTO - NOTNLM
OT  - COVID-19
OT  - SARS-CoV-2
OT  - dendritic cells
OT  - immunopathogenesis
OT  - severe acute respiratory syndrome coronavirus 2
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/18 06:00
PMCR- 2022/02/21
CRDT- 2022/03/10 05:44
PHST- 2021/12/25 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/03/10 05:44 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2022/02/21 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.843342 [doi]
PST - epublish
SO  - Front Immunol. 2022 Feb 21;13:843342. doi: 10.3389/fimmu.2022.843342. eCollection 
      2022.