PMID- 35265143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2022
DP  - 2022
TI  - The Role of PKC and HIF-1 and the Effect of Traditional Chinese Medicinal 
      Compounds on Cerebral Ischemia-Reperfusion Injury.
PG  - 1835898
LID - 10.1155/2022/1835898 [doi]
LID - 1835898
AB  - Neuronal death occurs during cerebral ischemia. However, when hemoperfusion and 
      oxygen supply are resumed to the ischemic focus of the brain tissue, the brain 
      tissue damage is further aggravated, resulting in cerebral ischemia-reperfusion 
      injury (CIRI) to the patients. Protein kinase C (PKC) plays an important role in 
      CIRI. Through the IP3/DAG/Ca(2+) signaling pathway, it promotes the influx of 
      calcium ions in neurons and causes calcium overload, which aggravates the damage. 
      At the same time, when brain cells are hypoxic, hypoxia-inducible factor-1 
      (HIF-1) is expressed, which regulates the expression of Bcl-2 and Bax through the 
      PI3K/Akt signaling pathway and reduces nerve cell injury. It also fights 
      hypoxic-ischemic injury by increasing the production of vascular endothelial 
      growth factor (VEGF) to promote blood vessel formation. The PKC and HIF-1 
      signaling pathways are also linked to CIRI. HIF-1 activates the PKC and ERK 
      pathways via the upregulation of VEGF, leading to increased Cx43 phosphorylation 
      and dysfunction and aggravating CIRI. Existing studies have shown that certain 
      traditional Chinese medicine (TCM) compounds regulate the PKC and HIF-1 signaling 
      pathways and alleviate CIRI. These compounds downregulate the PKC and the 
      activity of the PKC-related signaling pathways to alleviate CIRI. They can also 
      promote the expression of HIF-1, increase the content of VEGF in ischemic tissues 
      to promote the generation of blood vessels, and improve microcirculation. TCM 
      compounds can inhibit the cascade of reactions underlying disease occurrence and 
      development by targeting multiple components using different herbal formulations 
      to improve the structural and material changes in the brain cells, which 
      alleviate CIRI and protect the brain tissue. This study briefly describes the 
      role of PKC and HIF-1, their relationship in CIRI, and the effect of TCM on them.
CI  - Copyright (c) 2022 Zheyu Fang et al.
FAU - Fang, Zheyu
AU  - Fang Z
AUID- ORCID: 0000-0002-0374-9506
AD  - The First School of Clinical Medicine, Zhejiang Chinese Medical University, 
      Hangzhou 310053, China.
FAU - Zhang, Yangyang
AU  - Zhang Y
AUID- ORCID: 0000-0003-0989-0890
AD  - School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 
      310053, China.
FAU - Zhao, Xixi
AU  - Zhao X
AUID- ORCID: 0000-0003-3178-9561
AD  - School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 
      310053, China.
FAU - Jin, Weifeng
AU  - Jin W
AUID- ORCID: 0000-0001-9222-8819
AD  - School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 
      310053, China.
FAU - Yu, Li
AU  - Yu L
AUID- ORCID: 0000-0003-4133-5483
AD  - School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220227
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC8898791
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/11 06:01
PMCR- 2022/02/27
CRDT- 2022/03/10 05:44
PHST- 2021/11/03 00:00 [received]
PHST- 2022/01/26 00:00 [revised]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/03/10 05:44 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/11 06:01 [medline]
PHST- 2022/02/27 00:00 [pmc-release]
AID - 10.1155/2022/1835898 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2022 Feb 27;2022:1835898. doi: 
      10.1155/2022/1835898. eCollection 2022.