PMID- 35265721
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2022
DP  - 2022
TI  - Altered Phenotype of Circulating Dendritic Cells and Regulatory T Cells from 
      Patients with Acute Myocarditis.
PG  - 8873146
LID - 10.1155/2022/8873146 [doi]
LID - 8873146
AB  - Dendritic cells (DCs) and regulatory T cells (Tregs) play an essential role in 
      myocarditis. However, a particular DC phenotype in this disease has not been 
      assessed. Herein, we aim to evaluate myeloid (mDCs) and plasmacytoid DC (pDC) 
      phenotype, as well as Treg levels from myocarditis patients and healthy controls. 
      Using multiparametric flow cytometry, we evaluated the levels of myeloid DCs 
      (mDCs), plasmacytoid DCs (pDCs), and Tregs in peripheral blood from myocarditis 
      patients (n = 16) and healthy volunteers (n = 16) and performed correlation 
      analysis with clinical parameters through Sperman test. DCs from myocarditis 
      patients showed a higher expression of costimulatory molecules while a diminished 
      expression of the inhibitory receptors, ILT2 and ILT4. Even more, Treg cells from 
      myocarditis patients displayed higher levels of FOXP3 compared to controls. 
      Clinically, the increased levels of mDCs and their higher expression of 
      costimulatory molecules correlate with a worse myocardial function, higher levels 
      of acute phase reactants, and higher cardiac enzymes. This study shows an 
      activating phenotype of circulating DCs from myocarditis patients. This 
      proinflammatory status may contribute to the pathogenesis and immune deregulation 
      in acute myocarditis.
CI  - Copyright (c) 2022 Paola del Carmen Guerra-de-Blas et al.
FAU - Guerra-de-Blas, Paola Del Carmen
AU  - Guerra-de-Blas PDC
AUID- ORCID: 0000-0003-3050-6865
AD  - The Mexican Emerging Infectious Diseases Clinical Research Network (LaRed), 
      Ciudad de Mexico, Mexico.
FAU - Cruz-Gonzalez, Daniela
AU  - Cruz-Gonzalez D
AUID- ORCID: 0000-0002-0261-2292
AD  - Medicina Molecular Y Traslacional, Centro de Investigacion en Ciencias de la 
      Salud Y Biomedicina, Facultad de Medicina, Universidad Autonoma de San Luis 
      Potosi, Mexico.
AD  - Nutrition Deparment, Universidad de Matehuala, Mexico.
FAU - Martinez-Shio, Elena B
AU  - Martinez-Shio EB
AUID- ORCID: 0000-0002-2125-534X
AD  - Medicina Molecular Y Traslacional, Centro de Investigacion en Ciencias de la 
      Salud Y Biomedicina, Facultad de Medicina, Universidad Autonoma de San Luis 
      Potosi, Mexico.
FAU - Gonzalez-Amaro, Roberto
AU  - Gonzalez-Amaro R
AUID- ORCID: 0000-0001-6025-7375
AD  - Medicina Molecular Y Traslacional, Centro de Investigacion en Ciencias de la 
      Salud Y Biomedicina, Facultad de Medicina, Universidad Autonoma de San Luis 
      Potosi, Mexico.
FAU - Gonzalez-Pacheco, Hector
AU  - Gonzalez-Pacheco H
AUID- ORCID: 0000-0002-4370-9963
AD  - Departamento de Urgencias Y Unidad Coronaria, Instituto Nacional de Cardiologia 
      "Ignacio Chavez", Ciudad de Mexico, Mexico.
FAU - Layseca-Espinosa, Esther
AU  - Layseca-Espinosa E
AUID- ORCID: 0000-0002-2824-5486
AD  - Medicina Molecular Y Traslacional, Centro de Investigacion en Ciencias de la 
      Salud Y Biomedicina, Facultad de Medicina, Universidad Autonoma de San Luis 
      Potosi, Mexico.
FAU - Escobedo-Uribe, Carlos D
AU  - Escobedo-Uribe CD
AUID- ORCID: 0000-0001-9425-5458
AD  - Departamento de Cardiologia, Facultad de Medicina, Universidad Autonoma de San 
      Luis Potosi, Mexico.
FAU - Monsivais-Urenda, Adriana E
AU  - Monsivais-Urenda AE
AUID- ORCID: 0000-0001-9962-4531
AD  - Medicina Molecular Y Traslacional, Centro de Investigacion en Ciencias de la 
      Salud Y Biomedicina, Facultad de Medicina, Universidad Autonoma de San Luis 
      Potosi, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20220228
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
SB  - IM
MH  - Dendritic Cells
MH  - Flow Cytometry
MH  - Humans
MH  - *Myocarditis
MH  - Phenotype
MH  - *T-Lymphocytes, Regulatory
PMC - PMC8901353
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/04/05 06:00
PMCR- 2022/02/28
CRDT- 2022/03/10 05:46
PHST- 2021/10/11 00:00 [received]
PHST- 2022/01/19 00:00 [revised]
PHST- 2022/02/05 00:00 [accepted]
PHST- 2022/03/10 05:46 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - 10.1155/2022/8873146 [doi]
PST - epublish
SO  - J Immunol Res. 2022 Feb 28;2022:8873146. doi: 10.1155/2022/8873146. eCollection 
      2022.