PMID- 35267524
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 5
DP  - 2022 Feb 26
TI  - Clinical Significance of Tumor-Infiltrating Conventional and Plasmacytoid 
      Dendritic Cells in Pancreatic Ductal Adenocarcinoma.
LID - 10.3390/cancers14051216 [doi]
LID - 1216
AB  - Dendritic cells (DCs) play a key role in the orchestration of antitumor immunity. 
      Activated DCs efficiently enhance antitumor effects mediated by natural killer 
      cells and T lymphocytes. Conversely, tolerogenic DCs essentially contribute to an 
      immunosuppressive tumor microenvironment. Thus, DCs can profoundly influence 
      tumor progression and clinical outcome of tumor patients. To gain novel insights 
      into the role of human DCs in pancreatic ductal adenocarcinoma (PDAC), we 
      explored the frequency, spatial organization, and clinical significance of 
      conventional DCs type 1 (cDC1s) and type 2 (cDC2s) and plasmacytoid DCs (pDCs) in 
      primary PDAC tissues. A higher density of whole tumor area (WTA)- and tumor 
      stroma (TS)-infiltrating cDC1s was significantly associated with better 
      disease-free survival (DFS). In addition, an increased frequency of 
      intraepithelial tumor-infiltrating cDC2s was linked to better DFS and overall 
      survival (OS). Furthermore, an increased density of WTA- and TS-infiltrating pDCs 
      tended to improve DFS. Moreover, a higher frequency of WTA- and TS-infiltrating 
      cDC1s and pDCs emerged as an independent prognostic factor for better DFS and OS. 
      These findings indicate that tumor-infiltrating DCs can significantly influence 
      the clinical outcome of PDAC patients and may contribute to the design of novel 
      treatment options that target PDAC-infiltrating DCs.
FAU - Plesca, Ioana
AU  - Plesca I
AD  - Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Benesova, Iva
AU  - Benesova I
AD  - Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Beer, Carolin
AU  - Beer C
AD  - Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Sommer, Ulrich
AU  - Sommer U
AD  - Institute of Pathology, University Hospital Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Muller, Luise
AU  - Muller L
AUID- ORCID: 0000-0002-6610-326X
AD  - Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Wehner, Rebekka
AU  - Wehner R
AD  - Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
FAU - Heiduk, Max
AU  - Heiduk M
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl 
      Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Aust, Daniela
AU  - Aust D
AD  - Institute of Pathology, University Hospital Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
FAU - Baretton, Gustavo
AU  - Baretton G
AD  - Institute of Pathology, University Hospital Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
FAU - Bachmann, Michael P
AU  - Bachmann MP
AUID- ORCID: 0000-0002-8029-5755
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
AD  - Tumor Immunology, University Cancer Center (UCC), University Hospital Carl Gustav 
      Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, 
      Helmholtz Center Dresden-Rossendorf, Bautzener Strasse 400, 01328 Dresden, 
      Germany.
FAU - Feldmann, Anja
AU  - Feldmann A
AD  - Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, 
      Helmholtz Center Dresden-Rossendorf, Bautzener Strasse 400, 01328 Dresden, 
      Germany.
FAU - Weitz, Jurgen
AU  - Weitz J
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl 
      Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Seifert, Lena
AU  - Seifert L
AUID- ORCID: 0000-0003-4763-8127
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl 
      Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Seifert, Adrian M
AU  - Seifert AM
AUID- ORCID: 0000-0002-5329-3164
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
AD  - Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl 
      Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Schmitz, Marc
AU  - Schmitz M
AD  - Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - National Center for Tumor Diseases (NCT), University Hospital Carl Gustav Carus, 
      TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
AD  - German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research 
      Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
LA  - eng
GR  - 03ZU1111LA/Federal Ministry of Education and Research/
GR  - 03ZU1111LB/Federal Ministry of Education and Research/
GR  - 01ZX1913C/Federal Ministry of Education and Research/
PT  - Journal Article
DEP - 20220226
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8909898
OTO - NOTNLM
OT  - dendritic cells
OT  - neoadjuvant chemotherapy
OT  - pancreatic cancer
OT  - tumor microenvironment
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/11 06:01
PMCR- 2022/02/26
CRDT- 2022/03/10 15:25
PHST- 2022/01/27 00:00 [received]
PHST- 2022/02/18 00:00 [revised]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2022/03/10 15:25 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/11 06:01 [medline]
PHST- 2022/02/26 00:00 [pmc-release]
AID - cancers14051216 [pii]
AID - cancers-14-01216 [pii]
AID - 10.3390/cancers14051216 [doi]
PST - epublish
SO  - Cancers (Basel). 2022 Feb 26;14(5):1216. doi: 10.3390/cancers14051216.