PMID- 35267747
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 14
IP  - 5
DP  - 2022 Feb 25
TI  - Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems.
LID - 10.3390/polym14050925 [doi]
LID - 925
AB  - Temperature excursions within a biological milieu can be effectively used to 
      induce drug release from thermosensitive drug-encapsulating nanoparticles. 
      Oncological hyperthermia is of particular interest, as it is proven to 
      synergistically act to arrest tumor growth when combined with optimally-designed 
      smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs 
      more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and 
      provide the spatial placement and temporal delivery of the drug into localized 
      anatomical sites. This paper reviews the fundamentals of thermosensitive 
      polymers, with a particular focus on thermoresponsive liposomal-based drug 
      delivery systems.
FAU - Abuwatfa, Waad H
AU  - Abuwatfa WH
AUID- ORCID: 0000-0002-2424-1736
AD  - Department of Chemical Engineering, College of Engineering, American University 
      of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
AD  - Materials Science and Engineering Program, College of Arts and Sciences, American 
      University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
FAU - Awad, Nahid S
AU  - Awad NS
AD  - Department of Chemical Engineering, College of Engineering, American University 
      of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
FAU - Pitt, William G
AU  - Pitt WG
AUID- ORCID: 0000-0002-6043-3452
AD  - Chemical Engineering Department, Brigham Young University, Provo, UT 84602, USA.
FAU - Husseini, Ghaleb A
AU  - Husseini GA
AUID- ORCID: 0000-0002-7244-3105
AD  - Department of Chemical Engineering, College of Engineering, American University 
      of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
AD  - Materials Science and Engineering Program, College of Arts and Sciences, American 
      University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220225
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC8912701
OTO - NOTNLM
OT  - critical solution temperature
OT  - hyperthermia
OT  - liposomes
OT  - lysolipids
OT  - polymers
OT  - thermosensitivity
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/11 06:01
PMCR- 2022/02/25
CRDT- 2022/03/10 15:26
PHST- 2022/01/20 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/03/10 15:26 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/11 06:01 [medline]
PHST- 2022/02/25 00:00 [pmc-release]
AID - polym14050925 [pii]
AID - polymers-14-00925 [pii]
AID - 10.3390/polym14050925 [doi]
PST - epublish
SO  - Polymers (Basel). 2022 Feb 25;14(5):925. doi: 10.3390/polym14050925.