PMID- 35267915
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 5
DP  - 2022 Feb 23
TI  - Feasibility and Effectiveness of a Preventive Care Program during the Compound 
      Humanitarian Crisis and COVID-19 Pandemic in Venezuela.
LID - 10.3390/nu14050939 [doi]
LID - 939
AB  - Effective preventive care programs are urgently needed during humanitarian 
      crises, as has been especially obvious during the COVID-19 pandemic. A pragmatic 
      trial was designed: hybridized intervention (Diabetes Prevention Program [DPP] + 
      medical nutrition therapy + liquid diet [LD]; LD group) vs. DPP only (DPP group). 
      The participants were adults who were overweight/obese and at high risk of type 2 
      diabetes mellitus (T2DM). The LD consisted of a "homemade" milk- and 
      fruit-juice-based beverage. Pandemic restrictions delayed the program by nine 
      months, tripled the amount of time required for screening, and reduced the total 
      sample to 60%. Eventually, 127 participants were randomized, and 94/127 
      participants (74.0%) completed the first phase. Participant dropout was 
      influenced by migration, COVID-19 symptoms, education level, and socioeconomic 
      status. In two months, the LD group lost 2.9 kg (p < 0.001) and the DPP group, 
      2.2 kg (p < 0.001) (between-group p = 0.170), with improvements in their 
      cardiometabolic risk factors. At this stage, the DPP was shown to be feasible and 
      effective, demonstrating weight loss with the improvement of cardiometabolic risk 
      factors in a primary setting in Venezuela, a middle-income country with a chronic 
      humanitarian crisis, during the COVID-19 pandemic.
FAU - Gonzalez-Rivas, Juan P
AU  - Gonzalez-Rivas JP
AUID- ORCID: 0000-0001-7676-7900
AD  - Departments of Global Health and Population and Epidemiology, Harvard T.H. Chan 
      School of Public Health, Harvard University, Boston, MA 02115, USA.
AD  - International Clinical Research Center (ICRC), St. Anne's University Hospital 
      (FNUSA) Brno, Pekarska 53, 656 91 Brno, Czech Republic.
AD  - Foundation for Clinic, Public Health, and Epidemiological Research of Venezuela 
      (FISPEVEN), Barquisimeto 3001, Venezuela.
FAU - Infante-Garcia, Maria M
AU  - Infante-Garcia MM
AD  - International Clinical Research Center (ICRC), St. Anne's University Hospital 
      (FNUSA) Brno, Pekarska 53, 656 91 Brno, Czech Republic.
AD  - Foundation for Clinic, Public Health, and Epidemiological Research of Venezuela 
      (FISPEVEN), Barquisimeto 3001, Venezuela.
FAU - Nieto-Martinez, Ramfis
AU  - Nieto-Martinez R
AUID- ORCID: 0000-0002-0575-7534
AD  - Departments of Global Health and Population and Epidemiology, Harvard T.H. Chan 
      School of Public Health, Harvard University, Boston, MA 02115, USA.
AD  - Foundation for Clinic, Public Health, and Epidemiological Research of Venezuela 
      (FISPEVEN), Barquisimeto 3001, Venezuela.
FAU - Mechanick, Jeffrey I
AU  - Mechanick JI
AUID- ORCID: 0000-0002-0657-588X
AD  - The Marie-Josee and Henry R. Kravis Center for Cardiovascular Health at Mount 
      Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY 10028, USA.
AD  - Division of Endocrinology, Diabetes and Bone, Icahn School of Medicine at Mount 
      Sinai, New York, NY 10028, USA.
FAU - Danaei, Goodarz
AU  - Danaei G
AUID- ORCID: 0000-0003-2456-5463
AD  - Departments of Global Health and Population and Epidemiology, Harvard T.H. Chan 
      School of Public Health, Harvard University, Boston, MA 02115, USA.
LA  - eng
GR  - BLSCHP-2004/Harvard T.H. Chan School of Public Health, Departments of Global 
      Health and Population and Epidemiology, Bernard Lown Scholars in Cardiovascular 
      Health Program/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220223
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adult
MH  - *COVID-19/epidemiology/prevention & control
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology/prevention & control
MH  - Feasibility Studies
MH  - Humans
MH  - Pandemics/prevention & control
MH  - SARS-CoV-2
MH  - Venezuela/epidemiology
PMC - PMC8912706
OTO - NOTNLM
OT  - COVID-19
OT  - humanitarian crisis
OT  - primary prevention
OT  - type 2 diabetes mellitus
COIS- J.I.M. has received honoraria from Abbott Nutrition for lectures and program 
      development. The other authors declare no conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/15 06:00
PMCR- 2022/02/23
CRDT- 2022/03/10 15:26
PHST- 2021/12/07 00:00 [received]
PHST- 2022/02/14 00:00 [revised]
PHST- 2022/02/17 00:00 [accepted]
PHST- 2022/03/10 15:26 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2022/02/23 00:00 [pmc-release]
AID - nu14050939 [pii]
AID - nutrients-14-00939 [pii]
AID - 10.3390/nu14050939 [doi]
PST - epublish
SO  - Nutrients. 2022 Feb 23;14(5):939. doi: 10.3390/nu14050939.