PMID- 35267929
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220531
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 5
DP  - 2022 Feb 23
TI  - Mechanism of Astragalus membranaceus Alleviating Acquired Hyperlipidemia Induced 
      by High-Fat Diet through Regulating Lipid Metabolism.
LID - 10.3390/nu14050954 [doi]
LID - 954
AB  - Astragalus membranaceus (AM) is a food and medicinal homologous plant. The 
      current research is aimed to investigate the beneficial effects and mechanisms of 
      AM in treating acquired hyperlipidemia. The network pharmacology and 
      bioinformatics analysis results showed 481 AM-related targets and 474 acquired 
      hyperlipidemia-associated targets, and 101 candidate targets were obtained 
      through the intersection, mainly enriched in endocrine resistance, AGE-RAGE in 
      diabetic complications and p53 signaling pathways. Quercetin, kaempferol, 
      calycosin, formononetin and isorhamnetin were determined as the candidate active 
      components of AM in the treatment of acquired hyperlipidemia. Moreover, key 
      targets of AM, namely, AKT serine/threonine kinase 1 (AKT1), vascular endothelial 
      growth factor A (VEGFA), cyclin D1 (CCND1) and estrogen receptor 1 (ESR1), were 
      screened out, which were closely related to adipogenesis, fatty acid metabolism 
      and bile acid metabolism. The subsequent animal experiments showed that AM 
      extract treatment improved the lipid profiles of the high-fat diet (HFD)-fed mice 
      by reducing lipogenesis and increasing lipolysis and lipid beta-oxidation, which 
      were associated with the downregulating of AKT1 and CCND1, and the upregulating 
      of VEGFA and ESR1 in liver and adipose tissue. Overall, AM alleviated acquired 
      hyperlipidemia through regulating lipid metabolism, and AKT1, VEGFA, CCND1 and 
      ESR1 might be the key targets.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Nutrition Science and Food Hygiene, Xiangya School of Public 
      Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
FAU - Zheng, Wenya
AU  - Zheng W
AUID- ORCID: 0000-0002-4101-9408
AD  - Department of Nutrition Science and Food Hygiene, Xiangya School of Public 
      Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
FAU - Yang, Jinxin
AU  - Yang J
AD  - Department of Nutrition Science and Food Hygiene, Xiangya School of Public 
      Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
FAU - Ali, Anwar
AU  - Ali A
AUID- ORCID: 0000-0003-3169-1804
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
FAU - Qin, Hong
AU  - Qin H
AUID- ORCID: 0000-0002-4578-5118
AD  - Department of Nutrition Science and Food Hygiene, Xiangya School of Public 
      Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
LA  - eng
GR  - 82073556/National Natural Science Foundation of China/
GR  - 2021JJ30906/Natural Science Foundation of Hunan Province/
PT  - Journal Article
DEP - 20220223
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adipose Tissue/drug effects/metabolism
MH  - Animals
MH  - *Astragalus propinquus
MH  - *Diet, High-Fat/adverse effects
MH  - *Drugs, Chinese Herbal/chemistry/pharmacology/therapeutic use
MH  - *Hyperlipidemias/drug therapy/etiology/metabolism
MH  - *Lipid Metabolism/drug effects
MH  - Mice
MH  - *Phytotherapy
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC8912611
OTO - NOTNLM
OT  - AKT1
OT  - Astragalus membranaceus
OT  - CCND1
OT  - ESR1
OT  - VEGFA
OT  - acquired hyperlipidemia
OT  - high-fat diet
OT  - lipid metabolism
OT  - network pharmacology
COIS- The authors declare that they have no competing interests.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/15 06:00
PMCR- 2022/02/23
CRDT- 2022/03/10 15:27
PHST- 2021/12/31 00:00 [received]
PHST- 2022/02/20 00:00 [revised]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/03/10 15:27 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2022/02/23 00:00 [pmc-release]
AID - nu14050954 [pii]
AID - nutrients-14-00954 [pii]
AID - 10.3390/nu14050954 [doi]
PST - epublish
SO  - Nutrients. 2022 Feb 23;14(5):954. doi: 10.3390/nu14050954.