PMID- 35268410
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220314
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 5
DP  - 2022 Feb 27
TI  - Topographic Relationships among Deep Optic Nerve Head Parameters in Patients with 
      Primary Open-Angle Glaucoma.
LID - 10.3390/jcm11051320 [doi]
LID - 1320
AB  - PURPOSE: To investigate the topographic relationships among the deep optic nerve 
      head (ONH) parameters representing myopic axial elongation or changes in the 
      lamina cribrosa (LC) in patients with primary open-angle glaucoma (POAG). 
      METHODS: Among patients with POAG who visited the clinic between January 2015 and 
      March 2017, the following deep ONH parameters were measured using spectral-domain 
      optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) 
      length, ONH tilt angle, optic canal (OC) obliqueness, and anterior LC insertion 
      depth (ALID). In addition, the angular locations of the maximal value of each 
      parameter were measured. We analyzed the correlations between the parameters, 
      correlations with axial length (AL), and the spatial correspondence with 
      glaucomatous ONH damage. RESULTS: A total of 100 eyes with POAG were included in 
      the analysis. The EOBT length, ONH tilt angle, and OC obliqueness were correlated 
      with each other and with AL, whereas ALID showed less correlation with the other 
      parameters and AL. The angular location where the three AL-related parameters had 
      maximum values was also correlated with the predominant region of the 
      glaucomatous ONH damage, while the angular location of the deepest ALID showed 
      less correlation. CONCLUSIONS: Among the deep ONH parameters, the AL-related 
      parameters EOBT length, ONH tilt angle, and OC obliqueness showed strong spatial 
      correspondence with glaucomatous ONH damage, whereas the LC-related parameter 
      ALID was less correlated with both AL and the region with glaucomatous ONH 
      damage. Further studies are needed to determine how these differences affect 
      glaucomatous ONH change.
FAU - Park, Do-Young
AU  - Park DY
AD  - Department of Ophthalmology, Yeungnam University Hospital, Yeungnam University 
      College of Medicine, Daegu 42415, Korea.
FAU - Noh, Hoon
AU  - Noh H
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul 06351, Korea.
FAU - Kee, Changwon
AU  - Kee C
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul 06351, Korea.
FAU - Han, Jong-Chul
AU  - Han JC
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul 06351, Korea.
AD  - Department of Medical Device, Management and Research, SAIHST, Sungkyunkwan 
      University, Seoul 06355, Korea.
LA  - eng
GR  - 2017R1D1A1B03034834/National Research Foundation of Korea/
GR  - 2020 Yeungnam University Research Grant/Yeungnam University Research Grant/
PT  - Journal Article
DEP - 20220227
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8910857
OTO - NOTNLM
OT  - lamina cribrosa
OT  - myopia
OT  - open-angle glaucoma
OT  - optic nerve head parameter
OT  - optical coherence tomography
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/11 06:01
PMCR- 2022/02/27
CRDT- 2022/03/10 15:29
PHST- 2021/12/30 00:00 [received]
PHST- 2022/02/19 00:00 [revised]
PHST- 2022/02/25 00:00 [accepted]
PHST- 2022/03/10 15:29 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/11 06:01 [medline]
PHST- 2022/02/27 00:00 [pmc-release]
AID - jcm11051320 [pii]
AID - jcm-11-01320 [pii]
AID - 10.3390/jcm11051320 [doi]
PST - epublish
SO  - J Clin Med. 2022 Feb 27;11(5):1320. doi: 10.3390/jcm11051320.