PMID- 35268586
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20220323
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 5
DP  - 2022 Feb 22
TI  - Anti-Biofilm and Anti-Hemolysis Activities of 10-Hydroxy-2-decenoic Acid against 
      Staphylococcus aureus.
LID - 10.3390/molecules27051485 [doi]
LID - 1485
AB  - Persistent infections caused by Staphylococcus aureus biofilms pose a major 
      threat to global public health. 10-Hydroxy-2-decenoic acid (10-HDA), a main fatty 
      acid in royal jelly, has been shown to possess various biological activities. The 
      purpose of this study was to explore the effects of 10-HDA on the biofilms and 
      virulence of S. aureus and its potential molecular mechanism. Quantitative 
      crystal violet staining indicated that 10-HDA significantly reduced the biofilm 
      biomass at sub-minimum inhibitory concentration (MIC) levels (1/32MIC to 1/2MIC). 
      Scanning electron microscope (SEM) observations demonstrated that 10-HDA 
      inhibited the secretion of extracellular polymeric substances, decreased 
      bacterial adhesion and aggregation, and disrupted biofilm architecture. Moreover, 
      10-HDA could significantly decrease the biofilm viability and effectively 
      eradicated the mature biofilms. It was also found that the hemolytic activity of 
      S. aureus was significantly inhibited by 10-HDA. qRT-PCR analyses revealed that 
      the expressions of global regulators sarA, agrA, and alpha-hemolysin gene hla were 
      downregulated by 10-HDA. These results indicate that 10-HDA could be used as a 
      potential natural antimicrobial agent to control the biofilm formation and 
      virulence of S. aureus.
FAU - Gao, Kuankuan
AU  - Gao K
AD  - State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu 
      University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
AD  - Key Laboratory of Shandong Microbial Engineering, Qilu University of Technology 
      (Shandong Academy of Sciences), Jinan 250353, China.
FAU - Su, Bei
AU  - Su B
AD  - State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu 
      University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
AD  - Key Laboratory of Shandong Microbial Engineering, Qilu University of Technology 
      (Shandong Academy of Sciences), Jinan 250353, China.
FAU - Dai, Jing
AU  - Dai J
AD  - Key Laboratory of Shandong Microbial Engineering, Qilu University of Technology 
      (Shandong Academy of Sciences), Jinan 250353, China.
FAU - Li, Piwu
AU  - Li P
AD  - State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu 
      University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
AD  - Key Laboratory of Shandong Microbial Engineering, Qilu University of Technology 
      (Shandong Academy of Sciences), Jinan 250353, China.
FAU - Wang, Ruiming
AU  - Wang R
AD  - State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu 
      University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
AD  - Key Laboratory of Shandong Microbial Engineering, Qilu University of Technology 
      (Shandong Academy of Sciences), Jinan 250353, China.
FAU - Yang, Xiaohui
AU  - Yang X
AUID- ORCID: 0000-0002-2493-2641
AD  - State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu 
      University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
AD  - Key Laboratory of Shandong Microbial Engineering, Qilu University of Technology 
      (Shandong Academy of Sciences), Jinan 250353, China.
LA  - eng
GR  - ZR2020MC049/Shandong Provincial Natural Science Foundation/
PT  - Journal Article
DEP - 20220222
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
SB  - IM
MH  - *Staphylococcus aureus
PMC - PMC8912057
OTO - NOTNLM
OT  - 10-hydroxy-2-decenoic acid
OT  - Staphylococcus aureus
OT  - biofilm
OT  - hemolytic activity
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/11 06:00
MHDA- 2022/03/24 06:00
PMCR- 2022/02/22
CRDT- 2022/03/10 15:30
PHST- 2022/01/28 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/02/18 00:00 [accepted]
PHST- 2022/03/10 15:30 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2022/02/22 00:00 [pmc-release]
AID - molecules27051485 [pii]
AID - molecules-27-01485 [pii]
AID - 10.3390/molecules27051485 [doi]
PST - epublish
SO  - Molecules. 2022 Feb 22;27(5):1485. doi: 10.3390/molecules27051485.