PMID- 35271482
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 323
DP  - 2022 Feb
TI  - MICROSCOPIC CHANGES OF THE KIDNEY IN EXPERIMENTAL HYPERHOMOCYSTEINEMIA ON THE 
      BACKGROUND OF HYPER- AND HYPOTHYROIDISM.
PG  - 116-122
AB  - Hyper- and hypothyroidism are two typical clinical conditions that can cause a 
      variety of metabolic changes, including impaired sulfur-containing amino acids 
      metabolism, increased risk of cardiovascular disease, renal dysfunction, and 
      renal failure. Hypothyroidism has been shown to be associated with increased 
      serum creatinine, decreased glomerular filtration rate, and an increased risk of 
      chronic kidney disease. At the same time, the pathophysiological mechanisms of 
      renal dysfunction induced by excessive iodothyronine secretion are poorly 
      understood. The aim of the study was to establish the reorganization of the 
      kidney structural components under the conditions of experimental 
      hyperhomocysteinemia (HHCy), hyper- and hypothyroidism and their combined 
      effects. Thiolactone HHCy was simulated by administering to animals exogenous 
      homocysteine ​​(HC) in the form of thiolactone at a dose of 100 mg/kg body weight 
      once a day for 28 days. Hyperthyroidism was simulated by daily administration of 
      L-thyroxine at a dose of 200 mug/kg on 21st day, hypothyroidism - daily 
      administration of mercazolyl at a dose of 10 mg/kg on 21st day. Separate groups 
      of animals were administered L-thyroxine and mercazolyl in parallel with HC. A 
      significant degree of dystrophic changes in the structural components of the 
      kidneys under conditions of simulated hyperthyroidism and HHCy was established. 
      Signs of vascular insufficiency in the kidneys were detected. Deformation of 
      renal corpuscles, single focal thickenings and destruction of the outer layer of 
      the renal corpuscle capsule were observed, there was a narrowing of the urinary 
      space in the capsule. Microscopic study of the kidneys of animals under the 
      combined effects of hypothyroidism and HHCy revealed the most significant 
      destructive-degenerative changes in the filtration and reabsorption apparatus of 
      the organ on the background of significant vascular disorders. An increase in 
      number of glomeruli and a decrease of the urinary space of the 
      Shumlyansky-Bowman's capsule were observed in the renal corpuscles. Podocytes 
      underwent significant destructive changes. Damage to the epithelium in the system 
      of tubules was manifested by cell hypertrophy. Under the conditions of simulated 
      HHCy, hyper- and hypothyroidism, and especially with their combined effect, there 
      are significant disorders of the vascular bed with remodeling of the vascular 
      wall. On the background of hemodynamic disorders, there are significant 
      destructive and dystrophic changes in the epitheliocytes of the renal corpuscles 
      of the Shumlyansky-Bowman's capsule, the proximal and distal tubules of the 
      nephron, the filtration and reabsorption apparatus of the nephrons of the organ.
FAU - Nechiporuk, V
AU  - Nechiporuk V
AD  - 1National Pirogov Memorial Medical University, Vinnytsia; Ukraine.
FAU - Nebesna, Z
AU  - Nebesna Z
AD  - 2I. Gorbachevsky Ternopil National Medical University of the Ministry of Health 
      of Ukraine.
FAU - Didyk, N
AU  - Didyk N
AD  - 1National Pirogov Memorial Medical University, Vinnytsia; Ukraine.
FAU - Mazur, O
AU  - Mazur O
AD  - 1National Pirogov Memorial Medical University, Vinnytsia; Ukraine.
FAU - Korda, M
AU  - Korda M
AD  - 2I. Gorbachevsky Ternopil National Medical University of the Ministry of Health 
      of Ukraine.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Animals
MH  - *Hyperhomocysteinemia/metabolism
MH  - *Hyperthyroidism/metabolism
MH  - *Hypothyroidism
MH  - Kidney/metabolism
MH  - Nephrons
EDAT- 2022/03/11 06:00
MHDA- 2022/03/15 06:00
CRDT- 2022/03/10 17:14
PHST- 2022/03/10 17:14 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2022 Feb;(323):116-122.