PMID- 35271674
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220531
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 3
DP  - 2022
TI  - Psychosomatic syndromes are associated with IL-6 pro-inflammatory cytokine in 
      heart failure patients.
PG  - e0265282
LID - 10.1371/journal.pone.0265282 [doi]
LID - e0265282
AB  - Psychosomatic syndromes have emerged as an important source of comorbidity in 
      cardiac patients and have been associated with increased risk for adverse 
      outcomes in patients with heart failure (HF). Understanding of the mechanisms 
      underlying this connection is limited, however immune activity represents a 
      possible pathway. While there have been numerous studies connecting immune 
      activity to psychosomatic psychopathology, there is a lack of research on 
      patients with HF. We examined forty-one consecutive outpatients affected by HF. 
      We assessed psychosomatic psychopathology using the Diagnostic Criteria for 
      Psychosomatic Research (DCPR) and the Patient Health Questionnaire-15 (PHQ-15). 
      The Psychosocial Index (PSI) was used for assessing stress and psychosocial 
      dimensions. Depression was evaluated with Beck Depression Inventory-II (BDI-II). 
      Circulating levels of proinflammatory cytokines IL-6 and TNF-alpha were 
      ascertained. Univariate and multivariable regression models were used to test for 
      associations between inflammatory cytokines and psychosomatic psychopathology 
      (i.e., DCPR syndromes, PHQ-15) and psychological dimensions (i.e., BDI-II, PSI). 
      A significant positive correlation was found between IL-6 levels and 
      psychosomatic psychopathology even when controlling for any confounding variables 
      (i.e., Body-mass index (BMI), New York Heart Association (NYHA) class, smoking 
      habits, alcohol consumption, statin use, aspirin use, beta blockers use, age, and 
      gender). In contrast, the associations between TNF-alpha levels were 
      non-significant. These findings can contribute to research in support of a 
      psychoneuroimmune connection between psychosomatic psychopathology and HF. 
      Findings also suggest the possibility that elevated IL-6 levels are more relevant 
      for the pathogenesis of psychosomatic syndromes than for depression in patients 
      with HF.
FAU - Altamura, Mario
AU  - Altamura M
AUID- ORCID: 0000-0002-5684-5403
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
FAU - D'Andrea, Giovanna
AU  - D'Andrea G
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
FAU - Angelini, Eleonora
AU  - Angelini E
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
FAU - Tortorelli, Fabio M P
AU  - Tortorelli FMP
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
FAU - Balzotti, Angela
AU  - Balzotti A
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
FAU - Porcelli, Piero
AU  - Porcelli P
AUID- ORCID: 0000-0002-2263-8051
AD  - Department of Psychological, Health and Territorial Sciences, D'Annunzio 
      University of Chieti-Pescara, Chieti, Italy.
FAU - Margaglione, Maurizio
AU  - Margaglione M
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
FAU - Brunetti, Natale D
AU  - Brunetti ND
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Cassano, Tommaso
AU  - Cassano T
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Bellomo, Antonello
AU  - Bellomo A
AD  - Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20220310
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cytokines
MH  - *Heart Failure
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Psychophysiologic Disorders/psychology
MH  - Syndrome
MH  - Tumor Necrosis Factor-alpha
PMC - PMC8912235
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/03/11 06:00
MHDA- 2022/05/04 06:00
PMCR- 2022/03/10
CRDT- 2022/03/10 17:14
PHST- 2021/11/03 00:00 [received]
PHST- 2022/02/24 00:00 [accepted]
PHST- 2022/03/10 17:14 [entrez]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2022/03/10 00:00 [pmc-release]
AID - PONE-D-21-35033 [pii]
AID - 10.1371/journal.pone.0265282 [doi]
PST - epublish
SO  - PLoS One. 2022 Mar 10;17(3):e0265282. doi: 10.1371/journal.pone.0265282. 
      eCollection 2022.