PMID- 35272204
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220524
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 101
DP  - 2022 Jul-Aug
TI  - Frailty index and adverse outcomes in older patients in haemodialysis.
PG  - 104673
LID - S0167-4943(22)00054-1 [pii]
LID - 10.1016/j.archger.2022.104673 [doi]
AB  - BACKGROUND: In older people, the prevalence frailty is inversely proportional to 
      renal function, therefore it is supposed to be the highest in haemodialysis 
      patients. However, frailty and its association with adverse outcomes have been 
      scarcely investigated in this population. The aim of the present study was to 
      characterize the frailty status and explore its association with hospitalization 
      and mortality in a cohort of older patients undergoing chronic haemodialysis. 
      MATERIALS AND METHODS: This is a retrospective longitudinal study based on data 
      from 105 older patients undergoing haemodialysis for at least 3 months. We 
      computed a 24-item frailty index (FI) based on sociodemographic, clinical and 
      biological data collected at baseline. During the follow-up, death and 
      hospitalizations events were recorded. Unadjusted and adjusted Cox proportional 
      hazard models were performed to test the association of frailty with 
      hospitalization and death. RESULTS: Mean age of the patients was 79.1 (SD 7.6) 
      years, and their mean FI was 0.23 (SD 0.10). About 55% of patients were 
      classified as frail (i.e., FI>/= 0.25). Patients were observed for 21 
      (interquartile range [IQR] 8-32) months. Overall, during the follow-up, 75% of 
      patients required hospitalization and 28% died. Frail subjects where at higher 
      risk of hospitalization (HR 1.60, 95% CI 1.00-2.57, p = 0.05) and of all-cause 
      mortality (HR 2.52, 95% CI 1.10-5.80, p = 0.03) CONCLUSIONS: : Frailty is highly 
      prevalent among older people undergoing haemodialysis. Frail individuals present 
      a higher risk of hospitalizations and mortality. The FI is a reliable tool to 
      study vulnerability in this population.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Soldati, Anna
AU  - Soldati A
AD  - Specialisation School in Geriatrics, University of Milan, Italy.
FAU - Poggi, Marta Maria
AU  - Poggi MM
AD  - Specialisation School in Geriatrics, University of Milan, Italy.
FAU - Azzolino, Domenico
AU  - Azzolino D
AD  - Department of Clinical and Community Sciences, University of Milan, Milan, Italy; 
      Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy. 
      Electronic address: domenico.azzolino@unimi.it.
FAU - Vettoretti, Simone
AU  - Vettoretti S
AD  - Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' 
      Granda Ospedale Maggiore Policlinico di Milano, Italy.
FAU - Cesari, Matteo
AU  - Cesari M
AD  - Specialisation School in Geriatrics, University of Milan, Italy; Department of 
      Clinical and Community Sciences, University of Milan, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220304
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Aged
MH  - Frail Elderly
MH  - *Frailty/epidemiology/etiology
MH  - Geriatric Assessment
MH  - Hospitalization
MH  - Humans
MH  - Longitudinal Studies
MH  - Renal Dialysis/adverse effects
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Aging
OT  - Chronic kidney disease
OT  - Dialysis
OT  - End-stage renal disease
OT  - Renal Function
EDAT- 2022/03/11 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/03/10 20:15
PHST- 2022/01/18 00:00 [received]
PHST- 2022/03/02 00:00 [revised]
PHST- 2022/03/03 00:00 [accepted]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/03/10 20:15 [entrez]
AID - S0167-4943(22)00054-1 [pii]
AID - 10.1016/j.archger.2022.104673 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2022 Jul-Aug;101:104673. doi: 
      10.1016/j.archger.2022.104673. Epub 2022 Mar 4.