PMID- 35272251
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20220725
IS  - 1879-033X (Electronic)
IS  - 0959-440X (Linking)
VI  - 74
DP  - 2022 Jun
TI  - Structural bases of T cell antigen receptor recognition in celiac disease.
PG  - 102349
LID - S0959-440X(22)00028-8 [pii]
LID - 10.1016/j.sbi.2022.102349 [doi]
AB  - Celiac disease (CeD) is a human leukocyte antigen (HLA)-linked autoimmune-like 
      disorder that is triggered by the ingestion of gluten or related storage 
      proteins. The majority of CeD patients are HLA-DQ2.5(+), with the remainder being 
      either HLA-DQ8(+) or HLA-DQ2.2(+). Structural studies have shown how deamidation 
      of gluten epitopes engenders binding to HLA-DQ2.5/8, which then triggers an 
      aberrant CD4(+) T cell response. HLA tetramer studies, combined with structural 
      investigations, have demonstrated that repeated patterns of TCR usage underpins 
      the immune response to some HLADQ2.5/8 restricted gluten epitopes, with distinct 
      TCR motifs representing common landing pads atop the HLA-gluten complexes. 
      Structural studies have provided insight into TCR specificity and 
      cross-reactivity towards gluten epitopes, as well as cross-reactivity to 
      bacterial homologues of gluten epitopes, suggesting that environmental factors 
      may directly play a role in CeD pathogenesis. Collectively, structural 
      immunology-based studies in the CeD axis may lead to new therapeutics/diagnostics 
      to treat CeD, and also serve as an exemplar for other T cell mediated autoimmune 
      diseases.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Ciacchi, Laura
AU  - Ciacchi L
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 
      3800, Australia.
FAU - Reid, Hugh H
AU  - Reid HH
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 
      3800, Australia.
FAU - Rossjohn, Jamie
AU  - Rossjohn J
AD  - Infection and Immunity Program and Department of Biochemistry and Molecular 
      Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 
      3800, Australia; Institute of Infection and Immunity, School of Medicine, Cardiff 
      University, Cardiff, CF14 4XN, United Kingdom. Electronic address: 
      Jamie.Rossjohn@monash.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220307
PL  - England
TA  - Curr Opin Struct Biol
JT  - Current opinion in structural biology
JID - 9107784
RN  - 0 (Epitopes)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - *Celiac Disease/metabolism
MH  - Epitopes
MH  - Glutens
MH  - Humans
MH  - Receptors, Antigen, T-Cell/chemistry
MH  - T-Lymphocytes/metabolism
EDAT- 2022/03/11 06:00
MHDA- 2022/06/15 06:00
CRDT- 2022/03/10 20:17
PHST- 2021/09/30 00:00 [received]
PHST- 2022/01/15 00:00 [revised]
PHST- 2022/01/30 00:00 [accepted]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2022/03/10 20:17 [entrez]
AID - S0959-440X(22)00028-8 [pii]
AID - 10.1016/j.sbi.2022.102349 [doi]
PST - ppublish
SO  - Curr Opin Struct Biol. 2022 Jun;74:102349. doi: 10.1016/j.sbi.2022.102349. Epub 
      2022 Mar 7.