PMID- 35272298
OWN - NLM
STAT- MEDLINE
DCOM- 20220804
LR  - 20220804
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 65
IP  - 4
DP  - 2022
TI  - Structure-Function Analysis of MP-3 Microperimetry versus Octopus Perimetry in 
      Central Glaucomatous Visual Field Defects.
PG  - 437-445
LID - 10.1159/000524005 [doi]
AB  - INTRODUCTION: The aim of this study was to compare the structure-function 
      relationship with microperimetry and Octopus perimetry in primary open-angle 
      glaucoma (POAG) patients with central visual field (VF) defects. METHODS: Forty 
      eyes of 24 patients with POAG were enrolled. Circumpapillary retinal nerve fiber 
      layer (cpRNFL) analysis measured by spectral-domain optical coherence tomography 
      (SD-OCT) of the superotemporal, temporal, and inferotemporal optic-nerve head 
      sectors were related to corresponding microperimetric and Octopus VF clusters 
      using the G2 grid-pattern with dynamic strategy, respectively. The 
      structure-function relationships of both devices were assessed via a segmented 
      regression, as well as linear regression across overall SD-OCT cpRNFL values and 
      outside normative (<1%) SD-OCT cpRNFL values. RESULTS: Linear and segmented 
      regression fits were similar with both devices. Across overall cpRNFL sectorial 
      values, structure-function relations for the superotemporal, temporal, and 
      inferotemporal sectors were R2 = 0.176 (p = <0.001), R2 = 0.008 (p = 0.069), and 
      R2 = 0.294 (p = <0.001) for microperimetry and R2 = 0.189 (p = <0.001), R2 = 
      0.020 (p = 0.002), and R2 = 0.326 (p = <0.001) for Octopus perimetry. For 
      corresponding values outside normative limits (<1%), the relationships were R2 = 
      0.113 (p = <0.001), R2 = 0.001 (p = 0.836), and R2 = 0.420 (p = <0.001) for 
      microperimetry and R2 = 0.192 (p = <0.001), R2 = 0.002, (p = 0.336), and R2 = 
      0.366 (p = <0.001) for Octopus perimetry. DISCUSSION/CONCLUSION: 
      Structure-function analysis was similar for both devices. Fundus-tracking should 
      be further evaluated in a longitudinal setting in patients affected by glaucoma.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Georgiev, Stefan
AU  - Georgiev S
AD  - Department of Ophthalmology, Hanusch Hospital, Vienna Institute for Research in 
      Ocular Surgery, Vienna, Austria, s.georgiev@viros.at.
FAU - Palkovits, Stefan
AU  - Palkovits S
AD  - Department of Ophthalmology, Hanusch Hospital, Vienna Institute for Research in 
      Ocular Surgery, Vienna, Austria.
FAU - Hirnschall, Nino
AU  - Hirnschall N
AD  - Department of Ophthalmology, Hanusch Hospital, Vienna Institute for Research in 
      Ocular Surgery, Vienna, Austria.
FAU - Schlatter, Andreas
AU  - Schlatter A
AD  - Department of Ophthalmology, Hanusch Hospital, Vienna Institute for Research in 
      Ocular Surgery, Vienna, Austria.
FAU - Leisser, Christoph
AU  - Leisser C
AD  - Department of Ophthalmology, Hanusch Hospital, Vienna Institute for Research in 
      Ocular Surgery, Vienna, Austria.
FAU - Findl, Oliver
AU  - Findl O
AD  - Department of Ophthalmology, Hanusch Hospital, Vienna Institute for Research in 
      Ocular Surgery, Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20220310
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
SB  - IM
MH  - Animals
MH  - *Glaucoma, Open-Angle/diagnosis
MH  - Humans
MH  - Nerve Fibers
MH  - *Octopodiformes
MH  - Retinal Ganglion Cells
MH  - Scotoma
MH  - Tomography, Optical Coherence/methods
MH  - Vision Disorders/diagnosis
MH  - Visual Field Tests/methods
MH  - Visual Fields
OTO - NOTNLM
OT  - Fundus-tracking
OT  - Glaucoma
OT  - MP-3
OT  - Microperimetry
OT  - Visual field
EDAT- 2022/03/11 06:00
MHDA- 2022/08/05 06:00
CRDT- 2022/03/10 20:17
PHST- 2021/07/27 00:00 [received]
PHST- 2022/03/06 00:00 [accepted]
PHST- 2022/03/11 06:00 [pubmed]
PHST- 2022/08/05 06:00 [medline]
PHST- 2022/03/10 20:17 [entrez]
AID - 000524005 [pii]
AID - 10.1159/000524005 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2022;65(4):437-445. doi: 10.1159/000524005. Epub 2022 Mar 10.