PMID- 35273567
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220425
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Elevated TyG Index Predicts Incidence of Contrast-Induced Nephropathy: A 
      Retrospective Cohort Study in NSTE-ACS Patients Implanted With DESs.
PG  - 817176
LID - 10.3389/fendo.2022.817176 [doi]
LID - 817176
AB  - BACKGROUND: Triglyceride-glucose (TyG) index is a reliable and specific biomarker 
      for insulin resistance and is associated with renal dysfunction. The present 
      study sought to explore the relationship between TyG index and the incidence of 
      contrast-induced nephropathy (CIN) in non-ST elevation acute coronary syndrome 
      (NSTE-ACS) patients implanted with drug-eluting stents (DESs). METHODS: A total 
      of 1108 participants were recruited to the study and assigned to two groups based 
      on occurrence of CIN. TyG index was calculated as ln [fasting triglycerides 
      (mg/dL) x fasting blood glucose (mg/dL)/2]. Baseline characteristics and 
      incidence of CIN were compared between the two groups. Logistic regression 
      analysis was performed to evaluate the relationship between TyG index and CIN. 
      RESULTS: The results showed that 167 participants (15.1%) developed CIN. Subjects 
      in the CIN group had a significantly higher TyG index compared with subjects in 
      the non-CIN group (8.9 +/- 0.7 vs. 9.3 +/- 0.7, P<0.001). TyG index was significantly 
      correlated with increased risk of CIN after adjusting for confounding factors 
      irrespective of diabetes mellitus status and exhibited a J-shaped non-linear 
      association. Subgroup analysis showed a significant gender difference in the 
      relationship between TyG index and CIN. Receiver operating characteristic (ROC) 
      curve analysis indicated that the risk assessment performance of TyG index was 
      superior compared with other single metabolic indexes. Addition of TyG index to 
      the baseline model increased the area under the curve from 0.713 (0.672-0.754) to 
      0.742 (0.702-0.782) and caused a reclassification improvement of 0.120 
      (0.092-0.149). CONCLUSION: The findings from the present study show that a high 
      TyG index is significantly and independently associated with incidence of CIN in 
      NSTE-ACS patients firstly implanted with DESs. Routine preoperative assessment of 
      TyG index can alleviate CIN and TyG index provides a potential target for 
      intervention in prevention of CIN.
CI  - Copyright (c) 2022 Li, Li, Qin, Luo, Wang, Qiao, Tang and Yan.
FAU - Li, Mingkang
AU  - Li M
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Li, Linqing
AU  - Li L
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Qin, Yuhan
AU  - Qin Y
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Luo, Erfei
AU  - Luo E
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
FAU - Qiao, Yong
AU  - Qiao Y
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
FAU - Tang, Chengchun
AU  - Tang C
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
FAU - Yan, Gaoliang
AU  - Yan G
AD  - Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220222
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Acute Coronary Syndrome/epidemiology
MH  - Blood Glucose/metabolism
MH  - Female
MH  - Glucose
MH  - Humans
MH  - Incidence
MH  - *Kidney Diseases
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Triglycerides
PMC - PMC8901499
OTO - NOTNLM
OT  - TyG index
OT  - contrast-induced nephropathy (CIN)
OT  - diabetes mellitus
OT  - insulin resistance
OT  - non-ST elevated acute coronary syndrome (NSTE-ACS)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/12 06:00
MHDA- 2022/04/26 06:00
PMCR- 2022/02/22
CRDT- 2022/03/11 05:39
PHST- 2021/11/18 00:00 [received]
PHST- 2022/01/17 00:00 [accepted]
PHST- 2022/03/11 05:39 [entrez]
PHST- 2022/03/12 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2022/02/22 00:00 [pmc-release]
AID - 10.3389/fendo.2022.817176 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Feb 22;13:817176. doi: 
      10.3389/fendo.2022.817176. eCollection 2022.