PMID- 35276639 OWN - NLM STAT- MEDLINE DCOM- 20220510 LR - 20220510 IS - 1878-0180 (Electronic) IS - 1878-0180 (Linking) VI - 129 DP - 2022 May TI - A comparative investigation on the mechanical properties and cytotoxicity of Cubic, Octet, and TPMS gyroid structures fabricated by selective laser melting of stainless steel 316L. PG - 105151 LID - S1751-6161(22)00074-1 [pii] LID - 10.1016/j.jmbbm.2022.105151 [doi] AB - Metallic lattice structures can be fabricated by selective laser melting (SLM) with purposefully designed pores and controlled pore sizes that can bio mimic the natural bone, providing adequate mechanical and biological support for the patients. Strut-based structures, like Cubic, Octet; and sheet-based structures, like triply periodic minimal surface (TPMS) gyroid, have been studied extensively in the past. However, it lacks enough comparative study on the mechanical properties and cytotoxicity among these structures. Therefore, Cubic, Octet, and TPMS gyroid of Stainless steel 316 L (SS316L) are designed, manufactured, and characterized at 40/50/60% relative densities in this study. Moreover, the flowability, density characteristics, and cytotoxicity of SS316L powder are validated to ascertain its suitability for 3D printing and implant application. Based on refining the Gibson-Ashby model, it is possible to predict or design the mechanical properties via adjusting the relative densities. The results indicate these structures demonstrated appropriate Young's modulus and outstanding biocompatibility. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Wang, Niyou AU - Wang N AD - Department of Mechanical Engineering, 9 Engineering Drive 1, National University of Singapore, 117575, Singapore. FAU - Meenashisundaram, Ganesh Kumar AU - Meenashisundaram GK AD - Singapore Institute of Manufacturing and Technology, 73 Nanyang Drive, 637662, Singapore. FAU - Chang, Shuai AU - Chang S AD - Department of Materials Science and Engineering, 9 Engineering Drive 1, National University of Singapore, 117576, Singapore; State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, China. FAU - Fuh, Jerry Ying Hsi AU - Fuh JYH AD - Department of Mechanical Engineering, 9 Engineering Drive 1, National University of Singapore, 117575, Singapore. FAU - Dheen, S Thameem AU - Dheen ST AD - Department of Anatomy, 4 Medical Drive, MD10, YLLSoM, National University of Singapore, 117594, Singapore. FAU - Senthil Kumar, A AU - Senthil Kumar A AD - Department of Mechanical Engineering, 9 Engineering Drive 1, National University of Singapore, 117575, Singapore. Electronic address: asenthil@nus.edu.sg. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220302 PL - Netherlands TA - J Mech Behav Biomed Mater JT - Journal of the mechanical behavior of biomedical materials JID - 101322406 RN - 12597-68-1 (Stainless Steel) SB - IM MH - Bone and Bones MH - Elastic Modulus MH - Humans MH - *Lasers MH - Porosity MH - *Stainless Steel OTO - NOTNLM OT - Cytotoxicity OT - Gibson-Ashby model OT - Lattice structures OT - Mechanical property OT - SS316L OT - Selective laser melting (SLM) EDAT- 2022/03/12 06:00 MHDA- 2022/05/11 06:00 CRDT- 2022/03/11 20:17 PHST- 2021/11/11 00:00 [received] PHST- 2021/12/08 00:00 [revised] PHST- 2022/02/27 00:00 [accepted] PHST- 2022/03/12 06:00 [pubmed] PHST- 2022/05/11 06:00 [medline] PHST- 2022/03/11 20:17 [entrez] AID - S1751-6161(22)00074-1 [pii] AID - 10.1016/j.jmbbm.2022.105151 [doi] PST - ppublish SO - J Mech Behav Biomed Mater. 2022 May;129:105151. doi: 10.1016/j.jmbbm.2022.105151. Epub 2022 Mar 2.