PMID- 35276894
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 3
DP  - 2022 Jan 26
TI  - Does a Higher Protein Diet Promote Satiety and Weight Loss Independent of 
      Carbohydrate Content? An 8-Week Low-Energy Diet (LED) Intervention.
LID - 10.3390/nu14030538 [doi]
LID - 538
AB  - Both higher protein (HP) and lower carbohydrate (LC) diets may promote satiety 
      and enhance body weight (BW) loss. This study investigated whether HP can promote 
      these outcomes independent of carbohydrate (CHO) content. 121 women with obesity 
      (BW: 95.1 +/- 13.0 kg, BMI: 35.4 +/- 3.9 kg/m2) were randomised to either HP (1.2 
      g/kg BW) or normal protein (NP, 0.8 g/kg BW) diets, in combination with either LC 
      (28 en%) or normal CHO (NC, 40 en%) diets. A low-energy diet partial diet 
      replacement (LEDpdr) regime was used for 8 weeks, where participants consumed 
      fixed-energy meal replacements plus one ad libitum meal daily. Four-day dietary 
      records showed that daily energy intake (EI) was similar between groups (p = 
      0.744), but the difference in protein and CHO between groups was lower than 
      expected. Following multiple imputation (completion rate 77%), decrease in mean 
      BW, fat mass (FM) and fat-free mass (FFM) at Week 8 in all was 7.5 +/- 0.7 kg (p < 
      0.001), 5.7 +/- 0.5 kg (p < 0.001), and 1.4 +/- 0.7 kg (p = 0.054) respectively, but 
      with no significant difference between diet groups. LC (CHOxWeek, p < 0.05), but 
      not HP, significantly promoted postprandial satiety during a preload challenge. 
      Improvements in blood biomarkers were unrelated to LEDpdr macronutrient 
      composition. In conclusion, HP did not promote satiety and BW loss compared to NP 
      LEDpdr, irrespective of CHO content.
FAU - Lim, Jia Jiet
AU  - Lim JJ
AUID- ORCID: 0000-0002-0861-9276
AD  - Human Nutrition Unit, School of Biological Sciences, University of Auckland, 
      Auckland 1024, New Zealand.
AD  - Riddet Institute, Palmerston North 4474, New Zealand.
FAU - Liu, Yutong
AU  - Liu Y
AD  - Human Nutrition Unit, School of Biological Sciences, University of Auckland, 
      Auckland 1024, New Zealand.
AD  - Department of Medicine, University of Auckland, Auckland 1010, New Zealand.
FAU - Lu, Louise Weiwei
AU  - Lu LW
AD  - Human Nutrition Unit, School of Biological Sciences, University of Auckland, 
      Auckland 1024, New Zealand.
AD  - High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand.
FAU - Barnett, Daniel
AU  - Barnett D
AD  - Department of Statistics, University of Auckland, Auckland 1010, New Zealand.
FAU - Sequeira, Ivana R
AU  - Sequeira IR
AUID- ORCID: 0000-0001-5414-9925
AD  - Human Nutrition Unit, School of Biological Sciences, University of Auckland, 
      Auckland 1024, New Zealand.
AD  - High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand.
FAU - Poppitt, Sally D
AU  - Poppitt SD
AUID- ORCID: 0000-0002-2214-8378
AD  - Human Nutrition Unit, School of Biological Sciences, University of Auckland, 
      Auckland 1024, New Zealand.
AD  - Riddet Institute, Palmerston North 4474, New Zealand.
AD  - Department of Medicine, University of Auckland, Auckland 1010, New Zealand.
AD  - High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand.
LA  - eng
GR  - 3711468/Riddet Institute Centre of Research Excellence (CoRE), New Zealand 
      Tertiary Education Commission/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220126
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
SB  - IM
MH  - Diet
MH  - *Diet, High-Protein
MH  - Dietary Carbohydrates
MH  - Female
MH  - Humans
MH  - Satiation
MH  - *Weight Loss
PMC - PMC8838013
OTO - NOTNLM
OT  - amino acids
OT  - appetite regulation
OT  - body composition
OT  - energy intake
OT  - gut peptides
OT  - low-energy diet
OT  - partial diet replacement
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/03/13 06:00
MHDA- 2022/03/16 06:00
PMCR- 2022/01/26
CRDT- 2022/03/12 01:01
PHST- 2021/12/11 00:00 [received]
PHST- 2022/01/22 00:00 [revised]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/03/12 01:01 [entrez]
PHST- 2022/03/13 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2022/01/26 00:00 [pmc-release]
AID - nu14030538 [pii]
AID - nutrients-14-00538 [pii]
AID - 10.3390/nu14030538 [doi]
PST - epublish
SO  - Nutrients. 2022 Jan 26;14(3):538. doi: 10.3390/nu14030538.