PMID- 35276905
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 3
DP  - 2022 Jan 27
TI  - Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic 
      Study of Hepatic Elemental Composition by Means of ICP-OES.
LID - 10.3390/nu14030546 [doi]
LID - 546
AB  - Trace element accumulation varies in different human tissues. Distribution of 
      several elements was found to be disrupted in the case of excessive alcohol 
      consumption, causing negative effects and exacerbation of pathological processes 
      in the liver. In this study, we analyzed the levels and interactions between 
      seven trace elements including calcium (Ca), cobalt (Co), chromium (Cr), copper 
      (Cu), iron (Fe), potassium (K), and magnesium (Mg), manganese (Mn), sodium (Na), 
      zinc (Zn), and selenium (Se) in individuals with alcohol-use disorder (AUD) and 
      patients without AUD (control group). The liver samples were collected during 
      autopsy from 39 individuals with AUD and 45 control subjects. Elemental 
      composition inductively coupled plasma optical emission spectrometry (ICP-OES) 
      after wet mineralization by nitric acid was applied for the evaluation of the 
      samples. Positive correlations dominated in the AUD group, mainly in relation to 
      Mg, which strongly positively correlated with Ca, Mn, Fe; K correlated with Mn 
      and Zn, and Cu positively correlated with K and Zn. The strongest positive 
      correlation in the AUD group was observed for the Mg-Mn pair (r = 0.87). 
      Significant statistical differences (p < 0.05) between the groups concerned the 
      average concentration of Co, Cu, Mn, and Mg, which were lower in the AUD group, 
      and Fe, the level of which was significantly higher in the AUD group compared to 
      the control group. Evaluation of the chronic alcohol consumption effect on the 
      accumulation of trace elements in the liver allows a better understanding of the 
      pathological processes taking place in this organ.
FAU - Baj, Jacek
AU  - Baj J
AUID- ORCID: 0000-0002-1372-8987
AD  - Department of Anatomy, Medical University of Lublin, Jaczewskiego 4 (Collegium 
      Anatomicum), 20-090 Lublin, Poland.
FAU - Teresinski, Grzegorz
AU  - Teresinski G
AD  - Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b 
      (Collegium Pathologicum), 20-090 Lublin, Poland.
FAU - Forma, Alicja
AU  - Forma A
AUID- ORCID: 0000-0001-8714-7627
AD  - Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b 
      (Collegium Pathologicum), 20-090 Lublin, Poland.
FAU - Flieger, Michal
AU  - Flieger M
AD  - Department of Anatomy, Medical University of Lublin, Jaczewskiego 4 (Collegium 
      Anatomicum), 20-090 Lublin, Poland.
FAU - Proch, Jedrzej
AU  - Proch J
AUID- ORCID: 0000-0003-0023-044X
AD  - Department of Analytical Chemistry, Faculty of Chemistry, Adam Mickiewicz 
      University, 89B Umultowska Street, 61-614 Poznan, Poland.
FAU - Niedzielski, Przemyslaw
AU  - Niedzielski P
AUID- ORCID: 0000-0002-2787-9057
AD  - Department of Analytical Chemistry, Faculty of Chemistry, Adam Mickiewicz 
      University, 89B Umultowska Street, 61-614 Poznan, Poland.
FAU - Grochowski, Cezary
AU  - Grochowski C
AD  - Laboratory of Virtual Man, Medical University of Lublin, Jaczewskiego 4 
      (Collegium Anatomicum), 20-439 Lublin, Poland.
FAU - Blicharska, Eliza
AU  - Blicharska E
AD  - Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4A, 
      20-093 Lublin, Poland.
FAU - Buszewicz, Grzegorz
AU  - Buszewicz G
AUID- ORCID: 0000-0001-7637-6387
AD  - Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b 
      (Collegium Pathologicum), 20-090 Lublin, Poland.
FAU - Bogucki, Jacek
AU  - Bogucki J
AUID- ORCID: 0000-0002-8683-545X
AD  - Department of Organic Chemistry, Medical University of Lublin, Chodzki 4A, 20-093 
      Lublin, Poland.
FAU - Majerek, Dariusz
AU  - Majerek D
AUID- ORCID: 0000-0002-0035-7187
AD  - Department of Applied Mathematics, University of Technology, Nadbystrzycka 38D, 
      20-618 Lublin, Poland.
FAU - Karakula, Kaja
AU  - Karakula K
AUID- ORCID: 0000-0003-1493-8502
AD  - Department of Psychiatry, Psychotherapy and Early Intervention, Medical 
      University of Lublin, Gluska 1 (SPSK Nr 1), 20-439 Lublin, Poland.
FAU - Czeczelewski, Marcin
AU  - Czeczelewski M
AUID- ORCID: 0000-0002-5576-4169
AD  - Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b 
      (Collegium Pathologicum), 20-090 Lublin, Poland.
FAU - Flieger, Jolanta
AU  - Flieger J
AUID- ORCID: 0000-0001-6881-3161
AD  - Department of Analytical Chemistry, Medical University of Lublin, Chodzki 4A, 
      20-093 Lublin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20220127
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Trace Elements)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - *Alcoholism
MH  - Humans
MH  - Liver/chemistry
MH  - Spectrum Analysis
MH  - *Trace Elements/analysis
MH  - Zinc/analysis
PMC - PMC8838438
OTO - NOTNLM
OT  - alcohol use disorder
OT  - hepatic
OT  - liver
OT  - macroelements
OT  - microelements
OT  - trace elements
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/13 06:00
MHDA- 2022/03/16 06:00
PMCR- 2022/01/27
CRDT- 2022/03/12 01:01
PHST- 2021/12/02 00:00 [received]
PHST- 2022/01/25 00:00 [revised]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/03/12 01:01 [entrez]
PHST- 2022/03/13 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2022/01/27 00:00 [pmc-release]
AID - nu14030546 [pii]
AID - nutrients-14-00546 [pii]
AID - 10.3390/nu14030546 [doi]
PST - epublish
SO  - Nutrients. 2022 Jan 27;14(3):546. doi: 10.3390/nu14030546.