PMID- 35277074
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20220315
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 3
DP  - 2022 Feb 8
TI  - Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic 
      Alterations in Mice.
LID - 10.3390/nu14030715 [doi]
LID - 715
AB  - Pancreatitis has been implicated in the development and progression of type 2 
      diabetes and cancer. The pancreas uptakes molecular iodine (I(2)), which has 
      anti-inflammatory and antioxidant effects. The present work analyzes whether oral 
      I(2) supplementation prevents the pancreatic alterations promoted by low doses of 
      streptozotocin (STZ). CD1 mice (12 weeks old) were divided into the following 
      groups: control; STZ (20 mg/kg/day, i.p. for five days); I(2) (0.2 mg/Kg/day in 
      drinking water for 15 days); and combined (STZ + I(2)). Inflammation (Masson's 
      trichrome and periodic acid-Schiff stain), hyperglycemia, decreased beta-cells and 
      increased alpha-cells in pancreas were observed in male and female animals with STZ. 
      These animals also showed pancreatic increases in immune cells and inflammation 
      markers as tumor necrosis factor-alpha, transforming growth factor-beta and 
      inducible nitric oxide synthase with a higher amount of activated pancreatic 
      stellate cells (PSCs). The I(2) supplement prevented the harmful effect of STZ, 
      maintaining normal pancreatic morphometry and functions. The elevation of the 
      nuclear factor erythroid-2 (Nrf2) and peroxisome proliferator-activated receptor 
      type gamma (PPARgamma) contents was associated with the preservation of normal 
      glycemia and lipoperoxidation. In conclusion, a moderated supplement of I(2) 
      prevents the deleterious effects of STZ in the pancreas, possibly through 
      antioxidant and antifibrotic mechanisms including Nrf2 and PPARgamma activation.
FAU - Rodriguez-Castelan, Julia
AU  - Rodriguez-Castelan J
AUID- ORCID: 0000-0001-9474-4315
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Juriquilla, 
      Queretaro 76230, Mexico.
FAU - Delgado-Gonzalez, Evangelina
AU  - Delgado-Gonzalez E
AUID- ORCID: 0000-0003-2605-4632
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Juriquilla, 
      Queretaro 76230, Mexico.
FAU - Varela-Floriano, Valentin
AU  - Varela-Floriano V
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Juriquilla, 
      Queretaro 76230, Mexico.
FAU - Anguiano, Brenda
AU  - Anguiano B
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Juriquilla, 
      Queretaro 76230, Mexico.
FAU - Aceves, Carmen
AU  - Aceves C
AUID- ORCID: 0000-0001-9418-8304
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Juriquilla, 
      Queretaro 76230, Mexico.
LA  - eng
GR  - 203919/PAPIIT/
GR  - 205920/PAPIIT/
PT  - Journal Article
DEP - 20220208
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 5W494URQ81 (Streptozocin)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/pathology/prevention & control
MH  - *Diabetes Mellitus, Type 2/prevention & control
MH  - Dietary Supplements
MH  - Female
MH  - *Iodine/pharmacology
MH  - Male
MH  - Mice
MH  - Pancreas
MH  - Streptozocin
PMC - PMC8840345
OTO - NOTNLM
OT  - Nrf2
OT  - PPARgamma
OT  - molecular iodine
OT  - pancreatitis
OT  - streptozotocin
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2022/03/13 06:00
MHDA- 2022/03/16 06:00
PMCR- 2022/02/08
CRDT- 2022/03/12 01:01
PHST- 2021/11/03 00:00 [received]
PHST- 2022/02/03 00:00 [revised]
PHST- 2022/02/04 00:00 [accepted]
PHST- 2022/03/12 01:01 [entrez]
PHST- 2022/03/13 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2022/02/08 00:00 [pmc-release]
AID - nu14030715 [pii]
AID - nutrients-14-00715 [pii]
AID - 10.3390/nu14030715 [doi]
PST - epublish
SO  - Nutrients. 2022 Feb 8;14(3):715. doi: 10.3390/nu14030715.