PMID- 3527822
OWN - NLM
STAT- MEDLINE
DCOM- 19861021
LR  - 20131121
IS  - 0301-5149 (Print)
IS  - 0301-5149 (Linking)
VI  - 63
DP  - 1986
TI  - Synthesis and antigenic activity of E. coli ST and its analogues.
PG  - 79-87
AB  - Several enterotoxigenic E. coli (ETEC) are common causes of diarrhea in man and 
      animals. These strains of E. coli produce two types of enterotoxins: heat-stable 
      (ST) and heat-labile (LT). These toxins are peptides of molecular weight 2000 and 
      90,000 daltons, respectively. It is proposed that the synthetic analogues of 
      these toxins could be effectively used as the vaccines against enterotoxigenic 
      activity of E. coli. In this paper we report the isolation and chemical 
      characterization of a heat-stable toxin STa. We also report the synthesis of this 
      toxin and its analogues and their biochemical and immunological characterization.
FAU - Bhatnagar, P K
AU  - Bhatnagar PK
FAU - Frantz, J C
AU  - Frantz JC
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Dev Biol Stand
JT  - Developments in biological standardization
JID - 0427140
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (heat stable toxin (E coli))
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, Bacterial/isolation & purification
MH  - Bacterial Toxins/*chemical synthesis/immunology/isolation & purification
MH  - Biological Assay
MH  - Enterotoxins/*chemical synthesis/immunology/isolation & purification
MH  - Escherichia coli/immunology
MH  - Escherichia coli Proteins
MH  - Mice
MH  - Oxidation-Reduction
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Dev Biol Stand. 1986;63:79-87.