PMID- 352783 OWN - NLM STAT- MEDLINE DCOM- 19780925 LR - 20141003 IS - 0016-450X (Print) IS - 0016-450X (Linking) VI - 69 IP - 3 DP - 1978 Jun TI - Effect of BCG cell-wall skeleton on metastasis of syngeneic tumor in rats, with special reference to lymphocyte trapping. PG - 311-5 AB - Oil-attached BCG cell-wall skeleton (BCG-CWS) was demonstrated to have an activity inducing lymphocyte trapping in the draining node in rats. It acts also as a potent adjuvant for the lymphocyte trapping when injected into the growing syngeneic transplantable tumor. Treatment with repeated intratumor injections into the primary tumor resulted in suppression of tumor growth in both primary and metastatic sites. Even when the primary tumor escaped regression, inhibitory effect on metastatic spread was attained by the therapy. The contribution of BCG-CWS to suppression of metastasis especially in the draining node was discussed from the point of lymphocyte trapping in the draining node. FAU - Ogura, T AU - Ogura T FAU - Namba, M AU - Namba M FAU - Hirao, F AU - Hirao F FAU - Yamawaki, M AU - Yamawaki M FAU - Azuma, I AU - Azuma I FAU - Yamamura, Y AU - Yamamura Y LA - eng PT - Journal Article PL - Japan TA - Gan JT - Gan JID - 0151745 RN - 0 (BCG Vaccine) SB - IM MH - Animals MH - *BCG Vaccine MH - Cell Wall/immunology MH - Fibrosarcoma/*therapy MH - Immunotherapy/methods MH - Lymph Nodes/immunology MH - Lymphatic Metastasis/*therapy MH - Lymphocytes/*immunology MH - Male MH - Mycobacterium bovis/*immunology MH - Rats MH - Sarcoma, Experimental/therapy EDAT- 1978/06/01 00:00 MHDA- 1978/06/01 00:01 CRDT- 1978/06/01 00:00 PHST- 1978/06/01 00:00 [pubmed] PHST- 1978/06/01 00:01 [medline] PHST- 1978/06/01 00:00 [entrez] PST - ppublish SO - Gan. 1978 Jun;69(3):311-5.