PMID- 35278568
OWN - NLM
STAT- MEDLINE
DCOM- 20220519
LR  - 20220519
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 829
DP  - 2022 Jul 10
TI  - Maternal DBP exposure promotes synaptic formation in offspring by activating 
      astrocytes via the AKT/NF-kappaB/IL-6/JAK2/STAT3 signaling pathway.
PG  - 154437
LID - S0048-9697(22)01530-3 [pii]
LID - 10.1016/j.scitotenv.2022.154437 [doi]
AB  - It has been demonstrated that activated astrocytes in the hypothalamus could 
      disrupt GnRH secretion in offspring after maternal di-n-butyl phthalate (DBP) 
      exposure, indicating that the effect of DBP on astrocyte activation and crosstalk 
      between astrocytes and neurons is still worthy of further investigation. In this 
      study, pregnant mice were intragastrically administered DBP dissolved in corn oil 
      from gestational days (GD) 12.5-21.5. Maternal DBP exposure resulted in 
      hippocampal astrocyte activation, abnormal synaptic formation, and reduced 
      autonomic and exploratory behavior in offspring on postnatal day (PND) 22. 
      Further studies identified that mono-n-butyl phthalate (MBP) induced astrocyte 
      activation and proliferation by activating the AKT/NF-kappaB/IL-6/JAK2/STAT3 
      signaling pathway. Moreover, upregulated thrombospondin 1 (TSP1) in activated 
      astrocytes regulated synaptic-related protein expression. This study highlights 
      the neurotoxicity of maternal DBP exposure to offspring, which provides new 
      insights into identifying potential molecular targets for the treatment of 
      diseases related to neurological development disorders in children.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Xia, Yunhui
AU  - Xia Y
AD  - Immunology and Reproduction Biology Laboratory & State Key Laboratory of 
      Analytical Chemistry for Life Science, Medical School, Nanjing University, 
      Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, 
      Nanjing University, Nanjing, Jiangsu 210093, China.
FAU - Chen, Junhan
AU  - Chen J
AD  - Immunology and Reproduction Biology Laboratory & State Key Laboratory of 
      Analytical Chemistry for Life Science, Medical School, Nanjing University, 
      Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, 
      Nanjing University, Nanjing, Jiangsu 210093, China.
FAU - Ma, Tan
AU  - Ma T
AD  - Institute of Translational Medicine, Medical College, Yangzhou University, 
      Yangzhou 225001, China; Jiangsu Key Laboratory of Experimental & Translational 
      Non-coding RNA Research, Yangzhou 225001, China.
FAU - Meng, Xiannan
AU  - Meng X
AD  - Cancer Institute, Xuzhou Medical University, Xuzhou, China; Center of Clinical 
      Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
FAU - Han, Xiaodong
AU  - Han X
AD  - Immunology and Reproduction Biology Laboratory & State Key Laboratory of 
      Analytical Chemistry for Life Science, Medical School, Nanjing University, 
      Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, 
      Nanjing University, Nanjing, Jiangsu 210093, China.
FAU - Li, Dongmei
AU  - Li D
AD  - Immunology and Reproduction Biology Laboratory & State Key Laboratory of 
      Analytical Chemistry for Life Science, Medical School, Nanjing University, 
      Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, 
      Nanjing University, Nanjing, Jiangsu 210093, China. Electronic address: 
      lidm@nju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220309
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - EC 2.7.10.2 (JAK2 protein, human)
RN  - EC 2.7.10.2 (Janus Kinase 2)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - *Astrocytes
MH  - *Dibutyl Phthalate/toxicity
MH  - Female
MH  - Humans
MH  - Interleukin-6
MH  - Janus Kinase 2
MH  - Maternal Exposure
MH  - Mice
MH  - NF-kappa B
MH  - Pregnancy
MH  - Proto-Oncogene Proteins c-akt
MH  - STAT3 Transcription Factor
MH  - Signal Transduction
OTO - NOTNLM
OT  - Di-n-butyl phthalate (DBP) astrocyte synaptic formation
COIS- Declaration of competing interest The authors report no conflicts of interest.
EDAT- 2022/03/13 06:00
MHDA- 2022/05/20 06:00
CRDT- 2022/03/12 20:10
PHST- 2021/12/07 00:00 [received]
PHST- 2022/03/04 00:00 [revised]
PHST- 2022/03/06 00:00 [accepted]
PHST- 2022/03/13 06:00 [pubmed]
PHST- 2022/05/20 06:00 [medline]
PHST- 2022/03/12 20:10 [entrez]
AID - S0048-9697(22)01530-3 [pii]
AID - 10.1016/j.scitotenv.2022.154437 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Jul 10;829:154437. doi: 10.1016/j.scitotenv.2022.154437. 
      Epub 2022 Mar 9.