PMID- 35278578
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20220414
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 354
DP  - 2022 May 1
TI  - Bisoprolol for treatment of symptomatic patients with obstructive hypertrophic 
      cardiomyopathy. The BASIC (bisoprolol AS therapy in hypertrophic cardiomyopathy) 
      study.
PG  - 22-28
LID - S0167-5273(22)00332-1 [pii]
LID - 10.1016/j.ijcard.2022.03.013 [doi]
AB  - AIMS: To evaluate the role of bisoprolol to control symptoms and left ventricular 
      outflow tract obstruction (LVOTO) in a consecutive cohort of adults with 
      hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: In this retrospective 
      study, patients with HCM with an LVOT gradient >/=50 mmHg after Valsalva manoeuvre 
      and New York Heart Association (NYHA) class II-III symptoms were assigned to 
      receive bisoprolol (starting at 1.25 mg daily). The initial dose was increased 
      every two weeks to achieve the target in LVOT gradient <30 mmHg or the maximum 
      tolerated dose. The primary endpoint was the achievement of a LVOT gradient 
      <30 mmHg and >/= 1 NYHA class improvement. The secondary endpoints were proportion 
      of patients with LVOT gradient <30 mmHg or < 50 mmHg, proportion of patients with 
      >/=1 NYHA class improvement, and change from baseline in LVOT gradient. Between 
      December 2001 and December 2020, 92 patients were enrolled into the study. 
      Sixteen (17%) patients on bisoprolol met the primary endpoint. Bisoprolol reduced 
      the LVOT gradient to less than 30 mmHg in 33 (36%) patients, to less than 50 mmHg 
      in 57 (62%), and improved NYHA class in 30 (33%). The mean reduction of LVOT 
      gradient on bisoprolol was 28 (+/-14) mmHg and the percentage reduction was 42 
      (+/-21) %. In 35 (38%) patients, bisoprolol did not reduce the gradient to less 
      than 50 mmHg requiring disopyramide and/or myectomy to achieve this goal. 
      CONCLUSION: Treatment with bisoprolol was well-tolerated and effective in 
      relieving obstruction and improving symptoms in a significant proportion of 
      patients with symptomatic obstructive HCM.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Monda, Emanuele
AU  - Monda E
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Lioncino, Michele
AU  - Lioncino M
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Palmiero, Giuseppe
AU  - Palmiero G
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Franco, Francesco
AU  - Franco F
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Rubino, Marta
AU  - Rubino M
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Cirillo, Annapaola
AU  - Cirillo A
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Verrillo, Federica
AU  - Verrillo F
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Fusco, Adelaide
AU  - Fusco A
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Caiazza, Martina
AU  - Caiazza M
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Mazzella, Marialuisa
AU  - Mazzella M
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Moscarella, Elisabetta
AU  - Moscarella E
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Dongiglio, Francesca
AU  - Dongiglio F
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Sepe, Joseph
AU  - Sepe J
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Pacileo, Giuseppe
AU  - Pacileo G
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Calabro, Paolo
AU  - Calabro P
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy.
FAU - Limongelli, Giuseppe
AU  - Limongelli G
AD  - Inherited and Rare Cardiovascular Diseases Unit, Department of Translational 
      Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 
      Via L. Bianchi, 80131 Naples, Italy; Institute of Cardiovascular Sciences, 
      University College of London and St. Bartholomew's Hospital, Grower Street, 
      London WC1E 6DD, UK. Electronic address: limongelligiuseppe@libero.it.
LA  - eng
PT  - Journal Article
DEP - 20220310
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - GFO928U8MQ (Disopyramide)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adult
MH  - Bisoprolol/therapeutic use
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging/drug therapy
MH  - Disopyramide/therapeutic use
MH  - Humans
MH  - Retrospective Studies
MH  - *Ventricular Outflow Obstruction/diagnostic imaging/drug therapy
OTO - NOTNLM
OT  - Bisoprolol
OT  - Hypertrophic cardiomyopathy
OT  - Therapy
EDAT- 2022/03/13 06:00
MHDA- 2022/04/15 06:00
CRDT- 2022/03/12 20:10
PHST- 2021/10/06 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/03/07 00:00 [accepted]
PHST- 2022/03/13 06:00 [pubmed]
PHST- 2022/04/15 06:00 [medline]
PHST- 2022/03/12 20:10 [entrez]
AID - S0167-5273(22)00332-1 [pii]
AID - 10.1016/j.ijcard.2022.03.013 [doi]
PST - ppublish
SO  - Int J Cardiol. 2022 May 1;354:22-28. doi: 10.1016/j.ijcard.2022.03.013. Epub 2022 
      Mar 10.