PMID- 352789
OWN - NLM
STAT- MEDLINE
DCOM- 19780915
LR  - 20181130
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 75
IP  - 2
DP  - 1978 Aug
TI  - Reversal of jejunal water secretion by glucose in rats exposed to coliform 
      enterotoxins.
PG  - 255-62
AB  - Glucose absorption and glucose-facilitated water transport were assessed in rats 
      exposed to semipurified preparations of the heat-labile (LT) and heat-stable (ST) 
      enterotoxins of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae 
      by in vivo jejunal perfusion of these toxins alone and with varying amounts of 
      glucose. Progressive increases in the glucose concentration of from 12 to 56 mM 
      resulted in incremental rises in water absorption from perfusates containing each 
      of these toxins, with similar delta water values to those for the electrolyte 
      perfusion solution without toxins. Water secretion was reversed to absorption by 
      the addition of 12 mM glucose when secretion was mild, but 24 mM was required to 
      achieve this in the presence of severe secretion; absolute values for water 
      transport did not return to normal in any instance. Glucose absorption from 
      solutions containing 24 and 56 mM glucose was severely reduced by all of the ST 
      toxins and marginally reduced by some of the LT toxins; the effect of LT was not 
      attributable to the toxin itself, however, but to another unidentified factor 
      present in LT, but not ST, preparations from both toxigenic and nontoxigenic 
      strains. These observations indicate that glucose-facilitated water transport 
      remains intact in intestinal tissue exposed to various coliform enterotoxins and 
      that this occurs despite the presence of impaired glucose absorption in some 
      instances. They provide a rational basis for treatment with oral 
      glucose-electrolyte solutions of persons whose diarrhea is caused by toxigenic 
      coliform bacteria.
FAU - Klipstein, F A
AU  - Klipstein FA
FAU - Engert, R F
AU  - Engert RF
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (Enterotoxins)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Body Water/*metabolism
MH  - Enterobacter
MH  - *Enterobacteriaceae
MH  - Enterotoxins/*pharmacology
MH  - Escherichia coli
MH  - Glucose/metabolism/*pharmacology
MH  - Hot Temperature
MH  - Intestinal Absorption/drug effects
MH  - Jejunum/*metabolism
MH  - Klebsiella pneumoniae
MH  - Rats
EDAT- 1978/08/01 00:00
MHDA- 1978/08/01 00:01
CRDT- 1978/08/01 00:00
PHST- 1978/08/01 00:00 [pubmed]
PHST- 1978/08/01 00:01 [medline]
PHST- 1978/08/01 00:00 [entrez]
AID - S0016508578001596 [pii]
PST - ppublish
SO  - Gastroenterology. 1978 Aug;75(2):255-62.