PMID- 35279796
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230123
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 201
IP  - 2
DP  - 2023 Feb
TI  - Evaluation of Serum Selenium and Copper Levels with Inflammatory Cytokines and 
      Indices of Oxidative Stress in Type 2 Diabetes.
PG  - 617-626
LID - 10.1007/s12011-022-03191-w [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a metabolic and multifactorial disease in 
      which inflammatory markers, oxidative stress, and certain trace elements seem to 
      have an essential role. This study investigated the relationship between serum 
      selenium and copper level with inflammatory cytokines and oxidative stress in 
      T2DM.In this case-control study, 30 patients with T2DM and 30 healthy individuals 
      were selected. Serum levels of copper and selenium were measured by atomic 
      absorption spectrometry, and TNF-alpha and IL-6 and oxidative stress markers were 
      measured by ELISA. The SPSS v.22 was used for data analysis and the significance 
      level is less than 5%.The mean age of patients was 52.9 +/- 10.4 years, and the 
      control group was 48.5 +/- 10.4 years. In this study, 53.3% were female, and 46.7% 
      were male. The levels of BMI (p = 0.002), systolic pressure (p = 0.034), insulin, 
      selenium, malondialdehyde, and glutathione peroxidase (p = 0.0001; each), insulin 
      resistance, copper, and superoxide dismutase, IL6, and TNF-alpha (p = 0.001; each) in 
      T2DM were significantly higher than the control group. While levels of lipid 
      profile, uric acid, creatinine, and diastolic pressure were not significantly 
      different between the two groups. Selenium and copper are related to insulin 
      resistance, and their increasing levels are associated with increased levels of 
      markers of oxidative stress and inflammatory cytokines (p < 0.05).Increased 
      levels of copper and selenium are associated with T2DM and this increase is also 
      associated with increased levels of TNF-alpha, IL-6, and oxidative stress in T2DM. 
      Therefore, controlling these markers can lead us to control this disease better.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Pouresmaeil, Vahid
AU  - Pouresmaeil V
AUID- ORCID: 0000-0003-1023-1032
AD  - Department of Biochemistry, Faculty of Medicine, Mashhad Medical Sciences, 
      Islamic Azad University, Mashhad, Iran. v.pouresmaeil@mshdiau.ac.ir.
AD  - Innovative Medical Research Center, Faculty of Medicine, Mashhad Medical 
      Sciences, Islamic Azad University, Mashhad, Iran. v.pouresmaeil@mshdiau.ac.ir.
FAU - Al Abudi, Ali Hakem
AU  - Al Abudi AH
AD  - Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
FAU - Mahimid, Ammar Hossein
AU  - Mahimid AH
AD  - Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
FAU - Sarafraz Yazdi, Mohammad
AU  - Sarafraz Yazdi M
AD  - Department of Internal Medicine, Faculty of Medicine, Mashhad Medical Sciences, 
      Islamic Azad University, Mashhad, Iran.
FAU - Es-Haghi, Ali
AU  - Es-Haghi A
AD  - Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220312
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 789U1901C5 (Copper)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - H6241UJ22B (Selenium)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Case-Control Studies
MH  - *Copper/blood
MH  - Cytokines/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - Insulin Resistance
MH  - Interleukin-6/metabolism
MH  - *Oxidative Stress
MH  - *Selenium/blood
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Copper
OT  - IL-6
OT  - Oxidative stress
OT  - Selenium
OT  - TNF-alpha
OT  - Type 2 diabetes
EDAT- 2022/03/14 06:00
MHDA- 2023/01/21 06:00
CRDT- 2022/03/13 20:33
PHST- 2022/02/07 00:00 [received]
PHST- 2022/03/02 00:00 [accepted]
PHST- 2022/03/14 06:00 [pubmed]
PHST- 2023/01/21 06:00 [medline]
PHST- 2022/03/13 20:33 [entrez]
AID - 10.1007/s12011-022-03191-w [pii]
AID - 10.1007/s12011-022-03191-w [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2023 Feb;201(2):617-626. doi: 10.1007/s12011-022-03191-w. 
      Epub 2022 Mar 12.