PMID- 35280463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220315
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 14
IP  - 2
DP  - 2022 Feb
TI  - Efficacy of flaxseed oil compared with fish oil supplementation in the treatment 
      of coronary heart disease: a retrospective study.
PG  - 396-404
LID - 10.21037/jtd-22-26 [doi]
AB  - BACKGROUND: Many studies have demonstrated the beneficial effects of omega-3 
      fatty acids in animal models and human diseases. Compared with commonly used fish 
      oil, flaxseed oil has better palatability. However, the relative efficacy of the 
      two types of oil on the cardiovascular health of type 2 diabetes mellitus (T2DM) 
      patients with coronary heart disease (CHD) is unclear. METHODS: This was a 
      retrospective study based on the prospectively maintained database of Hubei 
      Provincial Hospital of Traditional Chinese Medicine. Patients meeting the 
      inclusion criteria were enrolled and then divided into two groups: the flaxseed 
      oil group received 1,000 mg flaxseed oil, which contains 400 mg of alpha-Linolenic 
      acid, as their omega-3 fatty acid source; the fish oil group received 1,000 mg of 
      fish oil, which contains 250 mg of eicosapentaenoic acid and 150 mg of 
      docosahexaenoic acid. The primary outcome was cardiovascular risk biomarker 
      changes between the two groups. P values less than 0.05 were considered 
      statistically significant. RESULTS: A total of 120 patients were enrolled in the 
      present study: 60 in the flaxseed oil group and 60 in the fish oil group. After a 
      median follow-up of 10.0 weeks (95% CI: 8.4-11.6 weeks), flaxseed oil was found 
      to be significantly better at reducing serum insulin levels and high-sensitivity 
      C-reactive protein (hs-CRP) levels than fish oil (P=0.03 and P=0.02, 
      respectively). The effects of flaxseed oil and fish oil on homeostatic model 
      assessment for insulin resistance (HOMA-IR), fasting plasma glucose (FPG); body 
      weight, and body mass index (BMI) were found to be similar. Moreover, patients 
      who received flaxseed oil tended to have a better overall survival than those who 
      received fish oil, although the difference was not statistically significant 
      (P=0.067). CONCLUSIONS: Compared with fish oil, flaxseed oil was more effective 
      in reducing serum insulin levels and hs-CRP levels for T2DM patients with CHD. 
      For these patients, flaxseed oil might become a novel choice.
CI  - 2022 Journal of Thoracic Disease. All rights reserved.
FAU - Jiang, Wei
AU  - Jiang W
AD  - Department of Cardiothoracic Surgery, Hubei Provincial Hospital of Traditional 
      Chinese Medicine Affiliated to Hubei University of Traditional Chinese Medicine, 
      Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
FAU - Liang, Jiangshui
AU  - Liang J
AD  - Department of Cardiothoracic Surgery, Hubei Provincial Hospital of Traditional 
      Chinese Medicine Affiliated to Hubei University of Traditional Chinese Medicine, 
      Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
FAU - Xiong, Meng
AU  - Xiong M
AD  - Department of Cardiothoracic Surgery, Hubei Provincial Hospital of Traditional 
      Chinese Medicine Affiliated to Hubei University of Traditional Chinese Medicine, 
      Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
FAU - Dong, Yongqiang
AU  - Dong Y
AD  - Department of Cardiothoracic Surgery, Hubei Provincial Hospital of Traditional 
      Chinese Medicine Affiliated to Hubei University of Traditional Chinese Medicine, 
      Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC8902109
OTO - NOTNLM
OT  - Coronary heart disease (CHD)
OT  - flaxseed oil
OT  - omega-3 fatty acids
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://jtd.amegroups.com/article/view/10.21037/jtd-22-26/coif). The authors have 
      no conflicts of interest to declare.
EDAT- 2022/03/15 06:00
MHDA- 2022/03/15 06:01
PMCR- 2022/02/01
CRDT- 2022/03/14 05:11
PHST- 2021/10/09 00:00 [received]
PHST- 2022/01/20 00:00 [accepted]
PHST- 2022/03/14 05:11 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/15 06:01 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - jtd-14-02-396 [pii]
AID - 10.21037/jtd-22-26 [doi]
PST - ppublish
SO  - J Thorac Dis. 2022 Feb;14(2):396-404. doi: 10.21037/jtd-22-26.