PMID- 35280499
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - Compositional Alterations of Gut Microbiota in Patients with Diabetic Kidney 
      Disease and Type 2 Diabetes Mellitus.
PG  - 755-765
LID - 10.2147/DMSO.S347805 [doi]
AB  - PURPOSE: Emerging evidence has revealed that gut microbiota plays a pivotal role 
      in the pathogenesis of type 2 diabetes mellitus (T(2)DM) and diabetic kidney 
      disease (DKD). However, few studies have used metagenomic sequencing to analyze 
      the alterations of gut microbiota community in patients with early-stage DKD. 
      METHODS: We carried out metagenomic sequencing in fecal samples of 10 DKD 
      patients (DKD group) and 10 T(2)DM patients who appeared to be less prone to DKD 
      (non-DKD group), aiming to compare the composition and function of gut microbiota 
      between the DKD and non-DKD groups. RESULTS: The gut microbial community of the 
      DKD group was significantly different from that of the non-DKD group, 
      characterized by a marked increase in phylum Proteobacteria, genus 
      Selenomonadales, Neosynechococcus, Shigella, Bilophila, Acidaminococcus, species, 
      Escherichia coli, Bacteroides plebeius, Megasphaera elsdenii, Acidaminococcus 
      unclassified, and Bilophila wadsworthia. The amounts of species Citrobacter 
      farmeri and Syntrophaceticus schinkii were significantly and positively 
      correlated with the urinary albumin creatinine ratio in the DKD group. 
      Furthermore, functional analysis based on dbCAN and KEGG databases showed 
      aberrant lipopolysaccharide (LPS) biosynthesis and carbohydrate metabolism in the 
      gut microbiome of the DKD group. CONCLUSION: Our findings provided evidence for 
      alterations in the composition and function of gut microbiota in patients with 
      DKD versus the non-DKD group. These data may contribute to a more comprehensive 
      understanding of the pathological mechanisms of DKD.
CI  - (c) 2022 He et al.
FAU - He, Xin
AU  - He X
AD  - Dialysis Department of Nephrology Hospital, First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, 710061, People's Republic of China.
FAU - Sun, Jiping
AU  - Sun J
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Liu, Chao
AU  - Liu C
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Yu, Xiaoyang
AU  - Yu X
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Li, Huixian
AU  - Li H
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Zhang, Wenjing
AU  - Zhang W
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Geng, Yingzhou
AU  - Geng Y
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
FAU - Wang, Zhigang
AU  - Wang Z
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an, 710061, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220306
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8911313
OTO - NOTNLM
OT  - diabetic kidney disease
OT  - gut microbiota
OT  - metagenomics
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest for this work.
EDAT- 2022/03/15 06:00
MHDA- 2022/03/15 06:01
PMCR- 2022/03/06
CRDT- 2022/03/14 05:11
PHST- 2021/11/04 00:00 [received]
PHST- 2022/02/25 00:00 [accepted]
PHST- 2022/03/14 05:11 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/15 06:01 [medline]
PHST- 2022/03/06 00:00 [pmc-release]
AID - 347805 [pii]
AID - 10.2147/DMSO.S347805 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Mar 6;15:755-765. doi: 10.2147/DMSO.S347805. 
      eCollection 2022.