PMID- 35282056
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220315
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 10
IP  - 2
DP  - 2022 Jan
TI  - Eosinophils and associated parameters in different types of skin diseases related 
      to elevated eosinophil levels.
PG  - 73
LID - 10.21037/atm-22-99 [doi]
LID - 73
AB  - BACKGROUND: Eosinophils, basophils, white blood cells (WBC), and immunoglobulin E 
      (IgE) play major roles in the pathogenesis of atopic dermatitis (AD), bullous 
      pemphigoid (BP), drug reaction with eosinophilia and systemic symptoms (DRESS), 
      and hypereosinophilic syndrome (HES). This study aimed to describe these 
      parameters in different skin diseases and provide further information concerning 
      the underlying pathogenesis. METHODS: A cross-sectional study of blood test 
      results, including WBC count, peripheral eosinophil count, peripheral 
      basophil/WBC percentage, and IgE level, from 115 cases of AD, 75 cases of BP, 55 
      cases of DRESS, 119 cases of HES, and 621 healthy volunteers was performed in 
      China. Data from before and after treatment and the population distribution of 
      different diseases were compared and described. RESULTS: All participants showed 
      increased peripheral eosinophil counts, eosinophil/WBC ratios, IgE levels, and 
      decreased peripheral basophil counts, with variance among the different disease 
      groups. Peripheral eosinophil counts in HES patients and IgE level in AD patients 
      increased the most prominently. No significant correlation existed among 
      eosinophils, basophils, and IgE. An obvious decrease in eosinophil count was 
      demonstrated after treatment in all 4 diseases. CONCLUSIONS: Eosinophils, 
      basophils, and IgE exert functions in diverse skin diseases, presenting altered 
      peripheral blood test results. In some cases, these changes are demonstrated only 
      in the skin and not in the blood. Compared with the other parameters considered 
      in this study, eosinophils seemed to be a better biomarker for treatment effects, 
      regardless of the disease type.
CI  - 2022 Annals of Translational Medicine. All rights reserved.
FAU - Wu, Tong
AU  - Wu T
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Tang, Luyan
AU  - Tang L
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Feng, Yang
AU  - Feng Y
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Jia, Yanjing
AU  - Jia Y
AD  - Department of Nursing, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Li, Fei
AU  - Li F
AD  - Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
AD  - Department of Dermatology, Huashan Hospital Baoshan, Fudan University, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC8848371
OTO - NOTNLM
OT  - Basophils
OT  - atopic dermatitis (AD)
OT  - eosinophils
OT  - immunoglobulin E (IgE)
OT  - pemphigoid bullous
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://atm.amegroups.com/article/view/10.21037/atm-22-99/coif). The authors have 
      no conflicts of interest to declare.
EDAT- 2022/03/15 06:00
MHDA- 2022/03/15 06:01
PMCR- 2022/01/01
CRDT- 2022/03/14 05:30
PHST- 2021/11/18 00:00 [received]
PHST- 2022/01/14 00:00 [accepted]
PHST- 2022/03/14 05:30 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/15 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - atm-10-02-73 [pii]
AID - 10.21037/atm-22-99 [doi]
PST - ppublish
SO  - Ann Transl Med. 2022 Jan;10(2):73. doi: 10.21037/atm-22-99.