PMID- 35282431
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220425
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Triglyceride to High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio, a Simple 
      but Effective Indicator in Predicting Type 2 Diabetes Mellitus in Older Adults.
PG  - 828581
LID - 10.3389/fendo.2022.828581 [doi]
LID - 828581
AB  - BACKGROUND: A simple and readily available biomarker can provide an effective 
      approach for the surveillance of type 2 diabetes mellitus (T2DM) in the elderly. 
      In this research, we aim to evaluate the role of triglyceride to high-density 
      lipoprotein cholesterol (TG/HDL-C) ratio as an indicator for new-onset T2DM in an 
      elderly Chinese population aged over 75 years. METHODS: This longitudinal 
      retrospective cohort study was conducted using a free database from a health 
      check screening project in China. Participants with baseline TG and HDL 
      measurements were enrolled, and the data of T2DM development were collected. The 
      cumulative incident T2DM rates in different quintile groups of TG/HDL-C ratio (Q1 
      to Q5) were calculated and plotted. The independent effect of baseline TG/HDL-C 
      ratio on T2DM risk during the follow-up period was tested by the Cox proportional 
      hazard model. Subgroup analysis was also conducted to clarify the role of 
      TG/HDL-C ratio in specific populations. RESULTS: A total of 231 individuals 
      developed T2DM among 2,571 subjects aged over 75 years during follow-up. 
      Regardless of adjustment for potential confounding variables, elevated TG/HDL-C 
      ratio independently indicated a higher risk of incident T2DM [hazard ratio (HR) = 
      1.29; 95% confidence interval (CI), 1.14-1.47; P < 0.01. As compared with the 
      lowest quintile (Q1), elevated TG/HDL-C ratio quintiles (Q2 to Q5) were 
      associated with larger HR estimates of incident T2DM [HR (95% CI), 1.35 
      (0.85-2.17), 1.31 (0.83-2.06), 1.85 (1.20-2.85), and 2.10 (1.38-3.20), 
      respectively]. In addition, a non-linear correlation was found between TG/HDL-C 
      ratio and the risk of T2DM, and the slope of the curve decreased after the cutoff 
      point of 2.54. Subgroup analysis revealed a stronger positive correlation among 
      male individuals and those with body mass index <24 kg/m(2). CONCLUSIONS: 
      Increased TG/HDL-C ratio indicates a greater risk of new-onset T2DM regardless of 
      confounding variables. TG/HDL-C ratio is a simple but effective indicator in 
      predicting T2DM in older adults. More future investigations are warranted to 
      further promote the clinical application of TG/HDL-C ratio.
CI  - Copyright (c) 2022 Liu, Liu, Liu, Xin, Lyu and Fu.
FAU - Liu, Hongzhou
AU  - Liu H
AD  - Department of Endocrinology, The First Medical Center, Chinese PLA General 
      Hospital, Beijing, China.
AD  - Department of Endocrinology, First Hospital of Handan City, Handan, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Clinics of Cadre, Department of Outpatient, The First Medical Center, Chinese PLA 
      General Hospital, Beijing, China.
FAU - Liu, Jixiang
AU  - Liu J
AD  - Department of Cerebral Surgery, First Hospital of Handan City, Handan, China.
FAU - Xin, Shuanli
AU  - Xin S
AD  - Department of Cardiology, First Hospital of Handan City, Handan, China.
FAU - Lyu, Zhaohui
AU  - Lyu Z
AD  - Department of Endocrinology, The First Medical Center, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Fu, Xiaomin
AU  - Fu X
AD  - Department of Endocrinology, The First Medical Center, Chinese PLA General 
      Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220224
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Cholesterol, HDL
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Triglycerides
PMC - PMC8907657
OTO - NOTNLM
OT  - T2DM
OT  - high-density lipoprotein cholesterol
OT  - older population
OT  - triglyceride
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/15 06:00
MHDA- 2022/04/26 06:00
PMCR- 2022/01/01
CRDT- 2022/03/14 05:34
PHST- 2021/12/03 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/03/14 05:34 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.828581 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Feb 24;13:828581. doi: 
      10.3389/fendo.2022.828581. eCollection 2022.