PMID- 35282801
OWN - NLM
STAT- MEDLINE
DCOM- 20230223
LR  - 20230223
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 26
IP  - 4
DP  - 2023 Apr
TI  - Short-term administration of tibolone reduces inflammation and oxidative stress 
      in the hippocampus of ovariectomized rats fed high-fat and high-fructose.
PG  - 275-289
LID - 10.1080/1028415X.2022.2046964 [doi]
AB  - Inflammation and oxidative stress are critical events involved in 
      neurodegeneration. In animal models, it has been shown that chronic consumption 
      of a hypercaloric diet, which leads to inflammatory processes, affects the 
      hippocampus, a brain region fundamental for learning and memory processes. In 
      addition, advanced age and menopause are risk factors for neurodegeneration. 
      Hormone replacement therapy (HRT) ameliorates menopause symptoms. Tibolone (TB), 
      a synthetic hormone, exerts estrogenic, progestogenic and androgenic effects on 
      different tissues. We aimed to determine the effect of short-term TB 
      administration on oxidative stress and inflammation markers in the hippocampus of 
      ovariectomized rats fed a high-fat-and-fructose diet (HFFD). Adult female rats 
      were ovariectomized (OVX) and fed standard diet or HFFD-consisting of 10% lard 
      supplemented chow and 20% high-fructose syrup in the drinking water-and 
      administered vehicle or TB (1 mg/kg for seven days). Finally, we administered 
      hormone receptor antagonists (MPP, RU486 or FLU) to each of the OVX + HFFD + TB 
      groups. Bodyweight, triglycerides and cholesterol, oxidative stress and 
      inflammation markers, and the activity and expression of antioxidant enzymes were 
      quantified in the hippocampus of each experimental group. We observed that 
      short-term TB administration significantly reduced body weight, AGEs, MDA levels, 
      increased SOD and GPx activity, improved GSH/GSSG ratio, and reduced IL-6 and 
      TNF-alpha. Our findings suggest that short-term administration of TB decreases 
      oxidative stress and reduces inflammation caused by HFFD and early estrogenic 
      decline. These effects occurred via estrogen receptor alpha.
FAU - Estrada-Cruz, Norma A
AU  - Estrada-Cruz NA
AUID- ORCID: 0000-0003-4794-7093
AD  - Unidad de Investigacion Medica en Farmacologia, Centro Medico Nacional (CMN) 
      Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
FAU - Manuel-Apolinar, Leticia
AU  - Manuel-Apolinar L
AUID- ORCID: 0000-0001-8175-4215
AD  - Unidad de Investigacion Medica en Enfermedades Endocrinas, CMN Siglo XXI, IMSS, 
      Mexico City, Mexico.
FAU - Segura-Uribe, Julia J
AU  - Segura-Uribe JJ
AUID- ORCID: 0000-0002-0676-5667
AD  - Subdireccion de Gestion de la Investigacion, Hospital Infantil de Mexico Federico 
      Gomez, Mexico City, Mexico.
FAU - Almanza-Perez, Julio C
AU  - Almanza-Perez JC
AUID- ORCID: 0000-0002-9417-5500
AD  - Laboratorio de Farmacologia, Departamento de Ciencias de la Salud, UAM-I, Mexico 
      City, Mexico.
FAU - Fortis-Barrera, Angeles
AU  - Fortis-Barrera A
AUID- ORCID: 0000-0003-0923-501X
AD  - Laboratorio de Farmacologia, Departamento de Ciencias de la Salud, UAM-I, Mexico 
      City, Mexico.
FAU - Orozco-Suarez, Sandra
AU  - Orozco-Suarez S
AUID- ORCID: 0000-0001-5289-8500
AD  - Unidad de Investigacion Medica en Enfermedades Neurologicas, CMN Siglo XXI, IMSS, 
      Mexico City, Mexico.
FAU - Bautista-Poblet, Guadalupe
AU  - Bautista-Poblet G
AUID- ORCID: 0000-0001-7233-186X
AD  - Unidad de Investigacion Medica en Farmacologia, Centro Medico Nacional (CMN) 
      Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
FAU - Coyoy-Salgado, Angelica
AU  - Coyoy-Salgado A
AUID- ORCID: 0000-0001-7007-9509
AD  - Catedras CONACyT-Unidad de Investigacion Medica en Enfermedades Neurologicas, 
      IMSS, Mexico City, Mexico.
FAU - Guerra-Araiza, Christian
AU  - Guerra-Araiza C
AUID- ORCID: 0000-0002-7164-4116
AD  - Unidad de Investigacion Medica en Farmacologia, Centro Medico Nacional (CMN) 
      Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20220313
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 30237-26-4 (Fructose)
RN  - FF9X0205V2 (tibolone)
RN  - 0 (Hormones)
SB  - IM
MH  - Rats
MH  - Female
MH  - Animals
MH  - *Fructose/adverse effects
MH  - *Oxidative Stress
MH  - Inflammation/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Body Weight
MH  - Hippocampus/metabolism
MH  - Hormones/metabolism/pharmacology
OTO - NOTNLM
OT  - Overnutrition
OT  - estrogenic decline
OT  - high-fat-and-high-fructose diet
OT  - hippocampus
OT  - hormone receptor antagonists
OT  - hormone receptors
OT  - inflammation
OT  - oxidative stress
EDAT- 2022/03/15 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/03/14 05:38
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/03/14 05:38 [entrez]
AID - 10.1080/1028415X.2022.2046964 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2023 Apr;26(4):275-289. doi: 10.1080/1028415X.2022.2046964. Epub 
      2022 Mar 13.