PMID- 35283078
OWN - NLM
STAT- MEDLINE
DCOM- 20220609
LR  - 20220721
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 211
DP  - 2022 Aug
TI  - Exposure to multiple toxic metals and the risk of early embryonic arrest among 
      women undergoing assisted reproductive techniques.
PG  - 113072
LID - S0013-9351(22)00399-1 [pii]
LID - 10.1016/j.envres.2022.113072 [doi]
AB  - BACKGROUND: Early embryonic arrest is a great challenge for in vitro 
      fertilization. Whether exposure to toxic metals is associated with an increased 
      risk of early embryonic arrest warrants investigation. OBJECTIVES: Here, we 
      conducted a case-control study in infertile women to estimate the associations 
      between blood barium (Ba), arsenic (As), mercury (Hg), and lead (Pb) exposure 
      levels and the risk of early embryonic arrest. METHODS: Ba, As, Hg, and Pb 
      exposure levels in fasting blood collected from 74 infertile women (123 cycles) 
      with early embryonic arrest and 157 infertile women (180 cycles) without early 
      embryonic arrest were measured by ICP-MS. Bayesian kernel machine regression 
      (BKMR) was used to assess the association of exposure level of toxic metals 
      mixture with the risk of early embryonic arrest as well as to evaluate which 
      metal playing a leading role in the association, and then generalized estimating 
      equations (GEEs) were used to evaluate the relationship between the selected 
      harmful metal and the risk of early embryonic arrest. Finally, the potential 
      causes of early embryonic arrest originating from the harmful metal exposure were 
      explored. RESULTS: Blood Ba levels were significantly higher in the case group 
      than that in the control group (p = 0.009) rather than As, Pb and Hg. Results 
      from BKMR showed that exposure to toxic metals mixture increased the risk of 
      early embryonic arrest, with Ba playing a leading role (PIP = 0.9612). GEE 
      analysis showed that high Ba exposure level was related with the increased risk 
      of early embryonic arrest (p < 0.05) and it impacted on the oogenesis 
      significantly. CONCLUSIONS: Our study found that exposure to toxic metals mixture 
      was associated with the increased risk of early embryonic arrest, and Ba 
      contributed most to the increased risk. Higher Ba exposure in whole blood 
      corresponds to a higher risk of early embryonic arrest and impacted on the 
      oogenesis significantly.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Jiang, Tingting
AU  - Jiang T
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Hu, Yuan
AU  - Hu Y
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - He, Shitao
AU  - He S
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Jiang, Rui
AU  - Jiang R
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Yao, Yuyou
AU  - Yao Y
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle 
      (Anhui Medical University), Ministry of Education of the People's Republic of 
      China, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key 
      Laboratory of Population Health and Aristogenics / Key Laboratory of 
      Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical 
      University; No 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Jin, Zhongxiu
AU  - Jin Z
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle 
      (Anhui Medical University), Ministry of Education of the People's Republic of 
      China, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key 
      Laboratory of Population Health and Aristogenics / Key Laboratory of 
      Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical 
      University; No 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Shen, Juan
AU  - Shen J
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Tao, Fangbiao
AU  - Tao F
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle 
      (Anhui Medical University), Ministry of Education of the People's Republic of 
      China, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key 
      Laboratory of Population Health and Aristogenics / Key Laboratory of 
      Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical 
      University; No 81 Meishan Road, Hefei, 230032, Anhui, China. Electronic address: 
      fbtao@ahmu.edu.cn.
FAU - Ji, Yanli
AU  - Ji Y
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle 
      (Anhui Medical University), Ministry of Education of the People's Republic of 
      China, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key 
      Laboratory of Population Health and Aristogenics / Key Laboratory of 
      Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical 
      University; No 81 Meishan Road, Hefei, 230032, Anhui, China. Electronic address: 
      jiyanlidev@126.com.
FAU - Liang, Chunmei
AU  - Liang C
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China; Department of Obstetrics and Gynecology, The First 
      Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, 230022, 
      Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui 
      Medical University), Ministry of Education of the People's Republic of China, No 
      81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of 
      Population Health and Aristogenics / Key Laboratory of Environmental Toxicology 
      of Anhui Higher Education Institutes, Anhui Medical University; No 81 Meishan 
      Road, Hefei, 230032, Anhui, China. Electronic address: liang_chun_mei@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220310
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 2P299V784P (Lead)
RN  - FXS1BY2PGL (Mercury)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - *Arsenic/toxicity
MH  - Bayes Theorem
MH  - Case-Control Studies
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - *Infertility, Female
MH  - Lead
MH  - *Mercury
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Case-control study
OT  - Early embryonic arrest
OT  - Toxic metal
EDAT- 2022/03/15 06:00
MHDA- 2022/06/10 06:00
CRDT- 2022/03/14 05:41
PHST- 2021/11/25 00:00 [received]
PHST- 2022/02/27 00:00 [revised]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/06/10 06:00 [medline]
PHST- 2022/03/14 05:41 [entrez]
AID - S0013-9351(22)00399-1 [pii]
AID - 10.1016/j.envres.2022.113072 [doi]
PST - ppublish
SO  - Environ Res. 2022 Aug;211:113072. doi: 10.1016/j.envres.2022.113072. Epub 2022 
      Mar 10.