PMID- 35283166
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220413
IS  - 1873-3700 (Electronic)
IS  - 0031-9422 (Linking)
VI  - 198
DP  - 2022 Jun
TI  - Phytochemical and biological studies on rare and endangered plants endemic to 
      China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of 
      the endangered conifer Torreya jackii and their bioactivities.
PG  - 113161
LID - S0031-9422(22)00077-2 [pii]
LID - 10.1016/j.phytochem.2022.113161 [doi]
AB  - A phytochemical investigation on the MeOH extract of the leaves and twigs of the 
      endangered conifer Torreya jackii Chun led to the isolation and characterization 
      of 21 structurally diverse diterpenoids. Among them, six are previously 
      undescribed, including four abietane-type (torreyins A-D, resp.) and two 
      labdane-type diterpenoids (torreyins E and F). Their structures and absolute 
      configurations were determined by a combination of spectroscopic methods, 
      calculated/experimental electronic circular dichroism (ECD) data, and 
      single-crystal X-ray diffraction analyses. In particular, torreyins A-C are rare 
      11,12-seco-abietane type diterpenoids possessing a dilactone moiety, and their 
      biosynthetic pathway starting from a co-occurring abietane derivative (i.e., 
      cyrtophyllone B) was briefly proposed. Among the isolates, 7-oxo-dehydroabietic 
      acid and 15-methoxy-7,13-abietadien-18-oic acid showed considerable inhibitory 
      effects against acetyl-coenzyme A carboxylase 1 (ACC1) and protein tyrosine 
      phosphatase 1 B (PTP1B), with IC(50) values of 3.1 and 6.8 muM, respectively.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Li, Hao
AU  - Li H
AD  - Institute of Natural Medicine and Health Products, School of Pharmaceutical 
      Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, 
      Taizhou University, Zhejiang, 318000, PR China; School of Pharmacy, Fudan 
      University, Shanghai, 201203, PR China.
FAU - Tang, Yu
AU  - Tang Y
AD  - School of Pharmacy, Fudan University, Shanghai, 201203, PR China.
FAU - Liang, Kai-Yuan
AU  - Liang KY
AD  - Institute of Natural Medicine and Health Products, School of Pharmaceutical 
      Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, 
      Taizhou University, Zhejiang, 318000, PR China; School of Pharmacy, Fudan 
      University, Shanghai, 201203, PR China.
FAU - Zang, Yi
AU  - Zang Y
AD  - State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 
      Chinese Academy of Science, Shanghai, 201203, PR China.
FAU - Osman, Ezzat E A
AU  - Osman EEA
AD  - School of Pharmacy, Fudan University, Shanghai, 201203, PR China; Department of 
      Biochemistry, Molecular Biology and Medicinal Chemistry, Theodor Bilharz Research 
      Institute, P. O. Box 30 Imbaba, Giza, 12411, Egypt.
FAU - Jin, Ze-Xin
AU  - Jin ZX
AD  - Institute of Natural Medicine and Health Products, School of Pharmaceutical 
      Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, 
      Taizhou University, Zhejiang, 318000, PR China.
FAU - Li, Jia
AU  - Li J
AD  - State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 
      Chinese Academy of Science, Shanghai, 201203, PR China.
FAU - Xiong, Juan
AU  - Xiong J
AD  - School of Pharmacy, Fudan University, Shanghai, 201203, PR China. Electronic 
      address: jxiong@fudan.edu.cn.
FAU - Li, Junmin
AU  - Li J
AD  - Institute of Natural Medicine and Health Products, School of Pharmaceutical 
      Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, 
      Taizhou University, Zhejiang, 318000, PR China. Electronic address: 
      lijm@tzc.edu.cn.
FAU - Hu, Jin-Feng
AU  - Hu JF
AD  - Institute of Natural Medicine and Health Products, School of Pharmaceutical 
      Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, 
      Taizhou University, Zhejiang, 318000, PR China; School of Pharmacy, Fudan 
      University, Shanghai, 201203, PR China. Electronic address: jfhu@tzc.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220310
PL  - England
TA  - Phytochemistry
JT  - Phytochemistry
JID - 0151434
RN  - 0 (Diterpenes)
RN  - 0 (Phytochemicals)
SB  - IM
MH  - *Diterpenes/chemistry
MH  - Molecular Structure
MH  - Phytochemicals/chemistry
MH  - Plant Leaves/chemistry
MH  - *Taxaceae
MH  - *Tracheophyta
OTO - NOTNLM
OT  - 11,12-Seco-abietane
OT  - Acetyl-coenzyme A carboxylase 1 (ACC1)
OT  - Diterpenoids
OT  - Protein tyrosine phosphatase 1B (PTP1B)
OT  - Rare and endangered plants (REPs)
OT  - Taxaceae
OT  - Torreya jackii
OT  - Torreyins
EDAT- 2022/03/15 06:00
MHDA- 2022/04/14 06:00
CRDT- 2022/03/14 05:42
PHST- 2021/12/05 00:00 [received]
PHST- 2022/03/04 00:00 [revised]
PHST- 2022/03/04 00:00 [accepted]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/03/14 05:42 [entrez]
AID - S0031-9422(22)00077-2 [pii]
AID - 10.1016/j.phytochem.2022.113161 [doi]
PST - ppublish
SO  - Phytochemistry. 2022 Jun;198:113161. doi: 10.1016/j.phytochem.2022.113161. Epub 
      2022 Mar 10.