PMID- 35283732
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220315
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 15
DP  - 2022
TI  - Early Fractional Amplitude of Low Frequency Fluctuation Can Predict the Efficacy 
      of Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Migraine 
      Without Aura.
PG  - 778139
LID - 10.3389/fnmol.2022.778139 [doi]
LID - 778139
AB  - Migraine is a common primary headache disorder. Transcutaneous auricular vagus 
      nerve stimulation (taVNS) has been verified to be effective in patients with 
      migraine without aura (MWoA). However, there are large interindividual 
      differences in patients' responses to taVNS. This study aimed to explore whether 
      pretreatment fractional amplitude of low frequency fluctuation (fALFF) features 
      could predict clinical outcomes in MWoA patients after 4-week taVNS. Sixty MWoA 
      patients and sixty well-matched healthy controls (HCs) were recruited, and 
      migraineurs received 4-week taVNS treatment. Resting-state functional magnetic 
      resonance imaging (rs-fMRI) data were collected, and the significant differences 
      of fALFF were detected between MWoA patients and HCs using two-sample t-test. A 
      mask of these significant regions was generated and used for subsequent analysis. 
      The abnormal fALFF in the mask was used to predict taVNS efficacy for MWoA using 
      a support vector regression (SVR) model combining with feature select of weight 
      based on the LIBSVM toolbox. We found that (1) compared with HCs, MWoA patients 
      exhibited increased fALFF in the left thalamus, left inferior parietal gyrus 
      (IPG), bilateral precentral gyrus (PreCG), right postcentral gyrus (PoCG), and 
      bilateral supplementary motor areas (SMAs), but decreased in the bilateral 
      precuneus and left superior frontal gyrus (SFG)/medial prefrontal cortex (mPFC); 
      (2) after 4-week taVNS treatment, the fALFF values significantly decreased in 
      these brain regions based on the pretreatment comparison. Importantly, the 
      decreased fALFF in the bilateral precuneus was positively associated with the 
      reduction in the attack times (r = 0.357, p = 0.005, Bonferroni correction, 
      0.05/5), whereas the reduced fALFF in the right PoCG was negatively associated 
      with reduced visual analog scale (VAS) scores (r = -0.267, p = 0.039, 
      uncorrected); (3) the SVR model exhibited a good performance for prediction (r = 
      0.411, p < 0.001),which suggests that these extracted fALFF features could be 
      used as reliable biomarkers to predict the treatment response of taVNS for MWoA 
      patients. This study demonstrated that the baseline fALFF features have good 
      potential for predicting individualized treatment response of taVNS in MWoA 
      patients, and those weight brain areas are mainly involved in the thalamocortical 
      (TC) circuits, default mode network (DMN), and descending pain modulation system 
      (DPMS). This will contribute to well understanding the mechanism of taVNS in 
      treating MWoA patients and may help to screen ideal patients who respond well to 
      taVNS treatment.
CI  - Copyright (c) 2022 Feng, Zhang, Wen, Hou, Ye, Fu, Luo and Liu.
FAU - Feng, Menghan
AU  - Feng M
AD  - Department of Radiology, The Second Affiliated Hospital of Guangzhou University 
      of Chinese Medicine, Guangzhou, China.
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - Department of Radiology, The Second Affiliated Hospital of Guangzhou University 
      of Chinese Medicine, Guangzhou, China.
FAU - Wen, Zeying
AU  - Wen Z
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
AD  - Department of Radiology, The First Affiliated Hospital of Henan University of 
      Chinese Medicine, Zhengzhou, China.
FAU - Hou, Xiaoyan
AU  - Hou X
AD  - Department of Radiology, The Second Affiliated Hospital of Guangzhou University 
      of Chinese Medicine, Guangzhou, China.
FAU - Ye, Yongsong
AU  - Ye Y
AD  - Department of Radiology, The Second Affiliated Hospital of Guangzhou University 
      of Chinese Medicine, Guangzhou, China.
FAU - Fu, Chengwei
AU  - Fu C
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
FAU - Luo, Wenting
AU  - Luo W
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
FAU - Liu, Bo
AU  - Liu B
AD  - Department of Radiology, The Second Affiliated Hospital of Guangzhou University 
      of Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220224
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC8908103
OTO - NOTNLM
OT  - fractional amplitude of low frequency fluctuation (fALFF)
OT  - functional magnetic resonance imaging (fMRI)
OT  - migraine without aura (MWoA)
OT  - support vector regression (SVR)
OT  - transcutaneous auricular vagus nerve stimulation (taVNS)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/15 06:00
MHDA- 2022/03/15 06:01
PMCR- 2022/01/01
CRDT- 2022/03/14 05:57
PHST- 2021/09/16 00:00 [received]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/03/14 05:57 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/15 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2022.778139 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2022 Feb 24;15:778139. doi: 10.3389/fnmol.2022.778139. 
      eCollection 2022.