PMID- 35284146
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2090-6641 (Print)
IS  - 2090-665X (Electronic)
IS  - 2090-665X (Linking)
VI  - 2022
DP  - 2022
TI  - Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic 
      Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case 
      Reports.
PG  - 9740225
LID - 10.1155/2022/9740225 [doi]
LID - 9740225
AB  - Successful kidney transplantation (KTx) in patients with antineutrophil 
      cytoplasmic antibody-associated vasculitis (AAV) has been reported with excellent 
      patient and graft survival rates. The recurrence of AAV in transplant recipients 
      is rare, and its mechanisms of action are not clearly known. The optimum time for 
      KTx and the relevance of ANCA titer at the time of transplantation remain 
      controversial. We report two cases of extremely rapid recurrent AAV after renal 
      transplantation; both were still ANCA-positive at the time of transplantation, 
      which led us to question the pathogenesis of ANCA antibodies in recurrence in a 
      kidney allograft. Apheresis plus immunosuppressive therapies were ineffective in 
      the first case and the patient became dialysis-dependent, whereas in the second 
      case methylprednisone pulses plus rituximab infusions resulted in long-lasting 
      remission.
CI  - Copyright (c) 2022 Reda Laamech et al.
FAU - Laamech, Reda
AU  - Laamech R
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
FAU - Naciri-Bennani, Hamza
AU  - Naciri-Bennani H
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
FAU - Giovannini, Diane
AU  - Giovannini D
AD  - Grenoble Alpes University, Grenoble, France.
AD  - Laboratory of Pathology, Grenoble University Hospital, Grenoble, France.
FAU - Noble, Johan
AU  - Noble J
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
AD  - Grenoble Alpes University, Grenoble, France.
FAU - Janbon, Benedicte
AU  - Janbon B
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
FAU - Malvezzi, Paolo
AU  - Malvezzi P
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
FAU - Jouve, Thomas
AU  - Jouve T
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
AD  - Grenoble Alpes University, Grenoble, France.
FAU - Rostaing, Lionel
AU  - Rostaing L
AUID- ORCID: 0000-0002-5130-7286
AD  - Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, 
      Grenoble University Hospital, Grenoble, France.
AD  - Grenoble Alpes University, Grenoble, France.
LA  - eng
PT  - Case Reports
DEP - 20220303
PL  - United States
TA  - Case Rep Nephrol
JT  - Case reports in nephrology
JID - 101598418
PMC - PMC8913059
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2022/03/15 06:00
MHDA- 2022/03/15 06:01
PMCR- 2022/03/03
CRDT- 2022/03/14 05:59
PHST- 2022/01/09 00:00 [received]
PHST- 2022/02/08 00:00 [accepted]
PHST- 2022/03/14 05:59 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/15 06:01 [medline]
PHST- 2022/03/03 00:00 [pmc-release]
AID - 10.1155/2022/9740225 [doi]
PST - epublish
SO  - Case Rep Nephrol. 2022 Mar 3;2022:9740225. doi: 10.1155/2022/9740225. eCollection 
      2022.